INT311473

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.38
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Ugt1a@ (Mus musculus)
Pain Link Frequency Relevance Heat
carbamazepine 12 99.34 Very High Very High Very High
Lamotrigine 113 98.60 Very High Very High Very High
antiepileptic Drug 22 92.80 High High
Gabapentin 3 49.56 Quite Low
anticonvulsant 3 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
sodium channel 1 5.00 Very Low Very Low Very Low
cocaine 1 5.00 Very Low Very Low Very Low
Neuropathic pain 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Convulsion 23 69.68 Quite High
Syndrome 9 67.80 Quite High
Partial Seizures 8 65.68 Quite High
Epilepsy 12 54.36 Quite High
Exanthema 18 5.00 Very Low Very Low Very Low
Vomiting 7 5.00 Very Low Very Low Very Low
Dizziness 4 5.00 Very Low Very Low Very Low
Diplopia 3 5.00 Very Low Very Low Very Low
Ataxia 3 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For instance, carbamazepine (CBZ) and phenytoin (PHT) are strong inducers of UGT1A4 and their combined treatment with LTG results in a substantial increase in its systemic clearance.12,13 Also, enzyme inducers (ie, CBZ, PHT) are responsible for the significant reduction in the LTG’s elimination half-life from approximately 24 to 13 h.12,13 In contrast, valproate (VPA) as an inhibitor of glucuronidation has been documented to significantly reduce the clearance of LTG with a concomitant increase in its elimination half-life from approximately 37 to 48 h.14 Moreover, LTG serum concentrations were significantly increased from 4.67 ± 3.66 (LTG monotherapy) to 9.56 ± 5.27 ?
Positive_regulation (inducers) of UGT1A4 associated with lamotrigine and carbamazepine
1) Confidence 0.04 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2874338 Disease Relevance 0.38 Pain Relevance 0.70

General Comments

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