INT311487

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Context Info
Confidence 0.26
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.70
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
leg 4
RLS (Homo sapiens)
Pain Link Frequency Relevance Heat
Gabapentin 328 99.84 Very High Very High Very High
anticonvulsant 6 94.34 High High
Pain 8 91.96 High High
Oxycodone 2 83.60 Quite High
agonist 6 78.96 Quite High
Dopamine 2 78.60 Quite High
Bioavailability 46 68.48 Quite High
Neuropathic pain 6 17.12 Low Low
gABA 10 5.00 Very Low Very Low Very Low
pregabalin 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Restless Legs Syndrome 72 100.00 Very High Very High Very High
Partial Seizures 2 96.50 Very High Very High Very High
Diabetes Mellitus 2 90.44 High High
Anxiety Disorder 2 89.48 High High
Vomiting 8 87.36 High High
Fatigue 2 86.48 High High
Dizziness 8 86.12 High High
Sleep Disorders 10 85.68 High High
Epilepsy 4 62.88 Quite High
Disease 2 51.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gabapentin is an anticonvulsant drug and is approved in the United States for the treatment of postherpetic neuralgia7 and partial seizures.7–10 Gabapentin has also been shown effective in improving RLS symptoms, reducing the frequency of periodic leg movements and improving sleep quality, suggesting a potential role in treating RLS.11–15 Gabapentin is not approved for the indication of RLS treatment, although it is often used off-label for this purpose.5,16,17 Additional placebocontrolled, double-blind clinical trials have also suggested potential uses of gabapentin in the treatment of painful neuropathies in patients with diabetes mellitus18 and anxiety disorders.19
Regulation (role) of Regulation (treating) of RLS in leg associated with pain, diabetes mellitus, anxiety disorder, anticonvulsant, restless legs syndrome, partial seizures and gabapentin
1) Confidence 0.26 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2874339 Disease Relevance 1.38 Pain Relevance 0.87
Gabapentin is an anticonvulsant drug and is approved in the United States for the treatment of postherpetic neuralgia7 and partial seizures.7–10 Gabapentin has also been shown effective in improving RLS symptoms, reducing the frequency of periodic leg movements and improving sleep quality, suggesting a potential role in treating RLS.11–15 Gabapentin is not approved for the indication of RLS treatment, although it is often used off-label for this purpose.5,16,17 Additional placebocontrolled, double-blind clinical trials have also suggested potential uses of gabapentin in the treatment of painful neuropathies in patients with diabetes mellitus18 and anxiety disorders.19
Neg (not) Regulation (approved) of Regulation (indication) of RLS in leg associated with pain, diabetes mellitus, anxiety disorder, anticonvulsant, restless legs syndrome, partial seizures and gabapentin
2) Confidence 0.26 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2874339 Disease Relevance 1.32 Pain Relevance 0.90

General Comments

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