INT311514

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Context Info
Confidence 0.35
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.89
Pain Relevance 2.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin2d) plasma membrane (Grin2d)
Anatomy Link Frequency
hippocampus 5
neurons 2
perirhinal cortex 1
Grin2d (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 982 100.00 Very High Very High Very High
Inflammation 16 99.84 Very High Very High Very High
Hippocampus 483 99.36 Very High Very High Very High
cINOD 7 98.42 Very High Very High Very High
antagonist 160 89.60 High High
long-term potentiation 182 87.60 High High
Nicotine 7 86.84 High High
Glutamate 175 72.32 Quite High
agonist 96 23.20 Low Low
cerebral cortex 84 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 16 99.84 Very High Very High Very High
Cognitive Disorder 175 98.84 Very High Very High Very High
Anxiety Disorder 14 97.24 Very High Very High Very High
Aging 798 93.60 High High
Targeted Disruption 17 81.88 Quite High
Stress 14 77.36 Quite High
Disease 56 76.28 Quite High
Urological Neuroanatomy 98 5.00 Very Low Very Low Very Low
Depression 64 5.00 Very Low Very Low Very Low
Sprains And Strains 49 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Figure 5C, the ratios of both subpopulations of interneurons were close to those of NMDA receptors with high Mg2+ sensitivity, suggesting that mainly NR2A/B, not NR2C/D subunits, are synaptically expressed on both EGFP+ (0.09 ± 0.01, n = 18) and EGFP- neurons (0.09 ± 0.01, n = 19).
Neg (not) Positive_regulation (mainly) of Neg (not) Gene_expression (expressed) of NR2C/D in neurons associated with nmda receptor
1) Confidence 0.35 Published 2010 Journal Mol Pain Section Body Doc Link PMC2879240 Disease Relevance 0 Pain Relevance 0.27
Likewise, sulindac, a non-steriodal anti-inflammatory drug (NSAID), attenuated age-related deficits in memory by decreasing inflammation, while increasing expression levels of the NMDA receptor subunits, GluN1 and GluN2B (Mesches et al., 2004).
Positive_regulation (increasing) of Gene_expression (expression) of GluN2B associated with inflammation, nmda receptor and cinod
2) Confidence 0.02 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.47 Pain Relevance 0.57
Likewise, sulindac, a non-steriodal anti-inflammatory drug (NSAID), attenuated age-related deficits in memory by decreasing inflammation, while increasing expression levels of the NMDA receptor subunits, GluN1 and GluN2B (Mesches et al., 2004).
Positive_regulation (increasing) of Gene_expression (levels) of GluN2B associated with inflammation, nmda receptor and cinod
3) Confidence 0.02 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.47 Pain Relevance 0.57
Overexpression of the GluN2B subunit gene enhances novel-object recognition, contextual and cued fear memory, fear extinction, spatial reference memory and social transmission of food preference, but not odor recognition memory (Tang et al., 1999; White and Youngentob, 2004; Cao et al., 2007).
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of GluN2B associated with cognitive disorder and anxiety disorder
4) Confidence 0.02 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.61 Pain Relevance 0.19
The enhanced memory in aged L-IFD mice appeared to be due to the enhanced expression of the GluN2B subunit in the hippocampus, as demonstrated by region-specific antagonism (Fontan-Lozano et al., 2007).
Positive_regulation (enhanced) of Gene_expression (expression) of GluN2B in hippocampus associated with hippocampus
5) Confidence 0.02 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.44 Pain Relevance 0.15
Recently, Chytrova et al. (2009) showed that both the actions of exercise and dietary supplementation of DHA in young adult rats enhances spatial memory and increases expression of the GluN2B subunit.
Positive_regulation (increases) of Gene_expression (expression) of GluN2B
6) Confidence 0.02 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.48 Pain Relevance 0.19
The L-IFD resulted in an increase in protein expression of the GluN2B subunit in both the hippocampus and perirhinal cortex (Fontan-Lozano et al., 2007).
Positive_regulation (increase) of Gene_expression (expression) of GluN2B in hippocampus associated with hippocampus
7) Confidence 0.02 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.21 Pain Relevance 0.15
The L-IFD resulted in an increase in protein expression of the GluN2B subunit in both the hippocampus and perirhinal cortex (Fontan-Lozano et al., 2007).
Positive_regulation (increase) of in perirhinal cortex Gene_expression (expression) of GluN2B in hippocampus associated with hippocampus
8) Confidence 0.01 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.21 Pain Relevance 0.15

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