INT311515

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 10
Disease Relevance 4.37
Pain Relevance 2.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin2d) plasma membrane (Grin2d)
Anatomy Link Frequency
hippocampus 9
brain 4
cerebral cortex 3
Grin2d (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 690 99.72 Very High Very High Very High
long-term potentiation 260 99.34 Very High Very High Very High
cerebral cortex 120 99.10 Very High Very High Very High
nMDA receptor 1290 99.06 Very High Very High Very High
Glutamate 240 93.92 High High
antagonist 200 59.12 Quite High
agonist 130 58.68 Quite High
Nicotine 10 56.48 Quite High
Inflammation 20 37.76 Quite Low
cINOD 10 36.24 Quite Low
Disease Link Frequency Relevance Heat
Disease 80 97.32 Very High Very High Very High
Targeted Disruption 20 91.36 High High
Aging 1140 90.84 High High
Urological Neuroanatomy 140 88.40 High High
Sprains And Strains 70 82.76 Quite High
Cognitive Disorder 250 82.16 Quite High
Stress 20 73.84 Quite High
INFLAMMATION 20 37.76 Quite Low
Depression 90 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 30 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together, these data suggest that expression of the GluN2B subunit is significantly decreased across species in both the cerebral cortex and in regions of the hippocampus in aged animals.


Negative_regulation (decreased) of Gene_expression (expression) of GluN2B in hippocampus associated with hippocampus and cerebral cortex
1) Confidence 0.02 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.50 Pain Relevance 0.23
There was no reversal of the age-related declines in GluN2B subunit mRNA expression with these calorie restriction protocols (Magnusson, 2001; Newton et al., 2007).
Negative_regulation (declines) of Gene_expression (expression) of GluN2B
2) Confidence 0.02 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.12 Pain Relevance 0.15
Significant reductions in GluN2B subunit expression have also been observed in the susceptible regions of brains with AD (Sze et al., 2001; Hynd et al., 2004).
Negative_regulation (reductions) of Gene_expression (expression) of GluN2B in brains associated with disease
3) Confidence 0.02 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.60 Pain Relevance 0.27
Likewise, in aged rats, dietary supplementation with n-3 PUFA reversed deficits in the expression of the GluN2B subunit (Dyall et al., 2007).
Negative_regulation (reversed) of Gene_expression (expression) of GluN2B
4) Confidence 0.02 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.55 Pain Relevance 0.14
Dietary supplementation with blueberry extract in aged rats rescues NMDA receptor-dependent LTP in the hippocampus, but did not prevent aged related declines in the protein expression of the GluN1 or GluN2B subunits (Coultrap et al., 2008).
Negative_regulation (declines) of Gene_expression (expression) of GluN2B in hippocampus associated with nmda receptor, hippocampus and long-term potentiation
5) Confidence 0.02 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.52 Pain Relevance 0.25
The visible decline in the expression of the GluN2B subunit post-development has been attributed to a programmed developmental switch from the GluN2B subunit to the GluN2A subunit in many brain regions (Liu et al., 2004).
Negative_regulation (decline) of Gene_expression (expression) of GluN2B in brain
6) Confidence 0.02 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0 Pain Relevance 0.13
In aged C57BL/6 mice, the mRNA expression of the GluN2B subunit declines significantly with age throughout the cerebral cortex and in some subregions of the hippocampus (Magnusson, 2000, 2001; Ontl et al., 2004; Magnusson et al., 2006).
Negative_regulation (declines) of Gene_expression (expression) of GluN2B in cerebral cortex associated with hippocampus and cerebral cortex
7) Confidence 0.02 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.45 Pain Relevance 0.40
In the cerebral cortex and hippocampus, there are also significant declines in the protein expression of GluN2B subunit (Magnusson et al., 2002, 2007; Ontl et al., 2004; Zhao et al., 2009b).
Negative_regulation (declines) of Gene_expression (expression) of GluN2B in hippocampus associated with hippocampus and cerebral cortex
8) Confidence 0.02 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.55 Pain Relevance 0.38
Dietary supplementation with blueberry extract in aged rats rescues NMDA receptor-dependent LTP in the hippocampus, but did not prevent aged related declines in the protein expression of the GluN1 or GluN2B subunits (Coultrap et al., 2008).
Negative_regulation (prevent) of Gene_expression (expression) of GluN2B in hippocampus associated with nmda receptor, hippocampus and long-term potentiation
9) Confidence 0.02 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.53 Pain Relevance 0.25
In the cerebral cortex and hippocampus, there are also significant declines in the protein expression of GluN2B subunit (Magnusson et al., 2002, 2007; Ontl et al., 2004; Zhao et al., 2009b).
Negative_regulation (declines) of in cerebral cortex Gene_expression (expression) of GluN2B in hippocampus associated with hippocampus and cerebral cortex
10) Confidence 0.01 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.55 Pain Relevance 0.38

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