INT311516

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Context Info
Confidence 0.32
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.62
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin2d) plasma membrane (Grin2d)
Anatomy Link Frequency
lamina 2
frontal cortex 2
Grin2d (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 208 97.88 Very High Very High Very High
Hippocampus 69 95.12 Very High Very High Very High
cerebral cortex 12 71.00 Quite High
Glutamate 31 66.72 Quite High
antagonist 40 40.00 Quite Low
Dorsal horn 13 36.16 Quite Low
long-term potentiation 26 5.00 Very Low Very Low Very Low
agonist 18 5.00 Very Low Very Low Very Low
GABAergic 14 5.00 Very Low Very Low Very Low
depression 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 114 100.00 Very High Very High Very High
Urological Neuroanatomy 14 98.48 Very High Very High Very High
Sprains And Strains 7 36.40 Quite Low
Cognitive Disorder 25 5.00 Very Low Very Low Very Low
Depression 10 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Targeted Disruption 5 5.00 Very Low Very Low Very Low
Neuropathic Pain 5 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results support our interpretation that both types of NR2 subunits, NR2A/B and NR2C/D are present on inhibitory interneurons of lamina II.
Regulation (present) of Localization (types) of NR2C/D in lamina
1) Confidence 0.32 Published 2010 Journal Mol Pain Section Body Doc Link PMC2879240 Disease Relevance 0 Pain Relevance 0.24
This suggests that, in addition to the declines already discussed in mRNA expression of the GluN2B subunit, there may be an additional effect of aging on GluN2B subunit localization within the synaptic membranes of the frontal cortex.
Regulation (effect) of Localization (localization) of GluN2B in frontal cortex associated with aging and urological neuroanatomy
2) Confidence 0.01 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.62 Pain Relevance 0.27

General Comments

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