INT311525

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.10
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gria1) endoplasmic reticulum (Gria1) plasma membrane (Gria1)
protein complex (Gria1)
Anatomy Link Frequency
synapse 2
Gria1 (Rattus norvegicus)
Ltp (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 258 100.00 Very High Very High Very High
long-term potentiation 52 100.00 Very High Very High Very High
agonist 26 100.00 Very High Very High Very High
Kinase C 2 75.60 Quite High
Glutamate 48 69.12 Quite High
depression 18 34.64 Quite Low
Hippocampus 138 5.00 Very Low Very Low Very Low
antagonist 40 5.00 Very Low Very Low Very Low
cerebral cortex 24 5.00 Very Low Very Low Very Low
Glutamate receptor 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 228 51.52 Quite High
Urological Neuroanatomy 28 40.00 Quite Low
Depression 18 34.64 Quite Low
Death 2 17.76 Low Low
Cognitive Disorder 50 5.00 Very Low Very Low Very Low
Disease 16 5.00 Very Low Very Low Very Low
Sprains And Strains 14 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 6 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An age-related decline in the GluN2B subunit within the synapse, with little or no change in the GluN2A (Magnusson, 2000; Magnusson et al., 2002) and GluN1 subunits could lead to a synaptic population of NMDA receptors that have decreased agonist affinity, faster kinetics, and reduced LTP associated with binding of calcium calmodulin kinase II (Kutsuwada et al., 1992; Monyer et al., 1992; Yamazaki et al., 1992; Ishii et al., 1993; Barria and Malinow, 2005) than in the young adult.
GluN1 Binding (associated) of LTP in synapse associated with nmda receptor, agonist and long-term potentiation
1) Confidence 0.00 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.05 Pain Relevance 0.37
An age-related decline in the GluN2B subunit within the synapse, with little or no change in the GluN2A (Magnusson, 2000; Magnusson et al., 2002) and GluN1 subunits could lead to a synaptic population of NMDA receptors that have decreased agonist affinity, faster kinetics, and reduced LTP associated with binding of calcium calmodulin kinase II (Kutsuwada et al., 1992; Monyer et al., 1992; Yamazaki et al., 1992; Ishii et al., 1993; Barria and Malinow, 2005) than in the young adult.
GluN1 Binding (associated) of LTP in synapse associated with nmda receptor, agonist and long-term potentiation
2) Confidence 0.00 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.05 Pain Relevance 0.37

General Comments

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