INT311552

Context Info Confidence 0.67 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 15 Disease Relevance 21.83 Pain Relevance 11.20

lyase activity (CA1) Golgi apparatus (CA1) cytoplasm (CA1)

Anatomy Link Frequency synovium 10 neurons 2 CA1 (Homo sapiens)

Pain Link Frequency Relevance Heat spinal inflammation 1118 99.84 Osteoarthritis 468 99.44 rheumatoid arthritis 494 99.16 Inflammation 99 92.04 Arthritis 13 89.72 cINOD 52 46.60 Ventral tegmentum 18 15.44 midbrain 4 13.20 Glutamate 34 5.00 Substantia nigra 24 5.00

Disease Link Frequency Relevance Heat Low Back Pain 1105 99.84 Hypercalcemia 143 99.72 Frailty 494 99.44 Rheumatoid Arthritis 494 99.16 Calcification 65 98.12 Hyperplasia 39 97.92 Disease 380 97.12 Stress 286 97.04 INFLAMMATION 137 92.04 Experimental Arthritis 13 89.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Compared to the average level of the OA samples, fluid samples from AS patients had a two-fold or greater increase in CA1 expression in 31 samples (77.5%).

Positive_regulation (increase) of Gene_expression (expression) of CA1 associated with spinal inflammation and osteoarthritis

1) Confidence 0.67 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 1.56 Pain Relevance 1.09

Increased CA1 expression in the synovium of AS patients may lead to improper mineralization by accelerating calcium salt deposition.

Positive_regulation (Increased) of Gene_expression (expression) of CA1 in synovium associated with spinal inflammation

2) Confidence 0.67 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 0.66 Pain Relevance 0.40

Our results suggest that elevated expression of CA1 in the diseased synovial tissues plays a role in new bone formation and bone resorption.

Positive_regulation (elevated) of Gene_expression (expression) of CA1 associated with hypercalcemia

3) Confidence 0.67 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 2.00 Pain Relevance 0.69

Overexpression of CA1 in the synovium of AS patients may be involved in bone resorption of the disease.

Positive_regulation (Overexpression) of Gene_expression (Overexpression) of CA1 in synovium associated with spinal inflammation, hypercalcemia and disease

4) Confidence 0.67 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 1.64 Pain Relevance 0.48

Therefore, overexpression of CA1 in the synovium of AS patients may lead to CaCO3 deposition in diseased tissues.

Positive_regulation (overexpression) of Gene_expression (overexpression) of CA1 in synovium associated with spinal inflammation

5) Confidence 0.67 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 0.51 Pain Relevance 0.35

The increased expression of CA1 was confirmed by individually investigating synovial samples from each disease using western blot analysis.

Positive_regulation (increased) of Gene_expression (expression) of CA1 associated with disease

6) Confidence 0.67 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 1.90 Pain Relevance 1.25

In the present study, a proteomic approach exclusively identified the increased expression of CA1 in AS synovial membranes as compared with RA and OA samples.

Positive_regulation (increased) of Gene_expression (expression) of CA1 associated with spinal inflammation, rheumatoid arthritis and osteoarthritis

7) Confidence 0.58 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 1.94 Pain Relevance 1.27

Among the five OA synovial samples, only one sample had a relatively high CA1 expression.

Positive_regulation (high) of Gene_expression (expression) of CA1 associated with osteoarthritis

8) Confidence 0.45 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 1.08 Pain Relevance 0.69

Increased expression of carbonic anhydrase I in the synovium of patients with ankylosing spondylitis Background

Positive_regulation (Increased) of Gene_expression (expression) of carbonic anhydrase I in synovium associated with spinal inflammation

9) Confidence 0.45 Published 2010 Journal BMC Musculoskelet Disord Section Title Doc Link PMC3012668 Disease Relevance 1.68 Pain Relevance 0.99

These results suggest that the overexpression of CA1 in the synovium of AS patients may accelerate calcification and bone resorption, which are two essential processes for new bone formation.

Positive_regulation (overexpression) of Gene_expression (overexpression) of CA1 in synovium associated with spinal inflammation, calcification and hypercalcemia

10) Confidence 0.45 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 2.18 Pain Relevance 1.01

The current study detected increased expression of CA1 in the synovial tissue of AS patients.

Positive_regulation (increased) of Gene_expression (expression) of CA1 associated with spinal inflammation

11) Confidence 0.45 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 2.25 Pain Relevance 0.98

Hence, overexpression of CA1 in the synovial tissues of AS patients may promote improper calcification and bone resorption in AS.

Positive_regulation (overexpression) of Gene_expression (overexpression) of CA1 associated with spinal inflammation, calcification and hypercalcemia

12) Confidence 0.45 Published 2010 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC3012668 Disease Relevance 1.29 Pain Relevance 0.70

The proteomic approach revealed significantly increased expression of carbonic anhydrase I (CA1) in the synovial membrane of patients with AS as compared with the RA and OA tissue samples.

Positive_regulation (increased) of Gene_expression (expression) of CA1 associated with spinal inflammation, rheumatoid arthritis and osteoarthritis

13) Confidence 0.45 Published 2010 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC3012668 Disease Relevance 2.14 Pain Relevance 1.30

The significantly higher expression of this gene in CA1 than in CA3 is an additional indication of endogenously higher levels of OS status in the CA1 region.

Positive_regulation (higher) of Gene_expression (expression) of CA1 associated with stress

14) Confidence 0.32 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 0.47 Pain Relevance 0

Nqo1 is one of the target genes of the key anti-oxidant transcription factor Nrf2, which is also significantly more active in CA1 neurons (Wang et al., 2005).

Positive_regulation (active) of Gene_expression (neurons) of CA1 in neurons

15) Confidence 0.30 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 0.51 Pain Relevance 0

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