INT311552
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Compared to the average level of the OA samples, fluid samples from AS patients had a two-fold or greater increase in CA1 expression in 31 samples (77.5%). | |||||||||||||||
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Increased CA1 expression in the synovium of AS patients may lead to improper mineralization by accelerating calcium salt deposition. | |||||||||||||||
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Our results suggest that elevated expression of CA1 in the diseased synovial tissues plays a role in new bone formation and bone resorption. | |||||||||||||||
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Overexpression of CA1 in the synovium of AS patients may be involved in bone resorption of the disease. | |||||||||||||||
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Therefore, overexpression of CA1 in the synovium of AS patients may lead to CaCO3 deposition in diseased tissues. | |||||||||||||||
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The increased expression of CA1 was confirmed by individually investigating synovial samples from each disease using western blot analysis. | |||||||||||||||
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In the present study, a proteomic approach exclusively identified the increased expression of CA1 in AS synovial membranes as compared with RA and OA samples. | |||||||||||||||
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Among the five OA synovial samples, only one sample had a relatively high CA1 expression. | |||||||||||||||
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Increased expression of carbonic anhydrase I in the synovium of patients with ankylosing spondylitis
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These results suggest that the overexpression of CA1 in the synovium of AS patients may accelerate calcification and bone resorption, which are two essential processes for new bone formation. | |||||||||||||||
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The current study detected increased expression of CA1 in the synovial tissue of AS patients. | |||||||||||||||
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Hence, overexpression of CA1 in the synovial tissues of AS patients may promote improper calcification and bone resorption in AS.
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The proteomic approach revealed significantly increased expression of carbonic anhydrase I (CA1) in the synovial membrane of patients with AS as compared with the RA and OA tissue samples. | |||||||||||||||
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The significantly higher expression of this gene in CA1 than in CA3 is an additional indication of endogenously higher levels of OS status in the CA1 region. | |||||||||||||||
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Nqo1 is one of the target genes of the key anti-oxidant transcription factor Nrf2, which is also significantly more active in CA1 neurons (Wang et al., 2005). | |||||||||||||||
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