INT311554

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Context Info
Confidence 0.69
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.22
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MAOA) small molecule metabolic process (MAOA) oxidoreductase activity (MAOA)
Anatomy Link Frequency
neurons 1
MAOA (Homo sapiens)
Pain Link Frequency Relevance Heat
monoamine 5 100.00 Very High Very High Very High
Substantia nigra 12 90.40 High High
Serotonin 8 88.64 High High
Neurotransmitter 11 86.56 High High
Dopamine 5 84.56 Quite High
sSRI 8 43.08 Quite Low
ischemia 12 27.92 Quite Low
Glutamate 17 24.40 Low Low
withdrawal 1 6.12 Low Low
long-term potentiation 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 43 96.16 Very High Very High Very High
Aggression 34 90.40 High High
Stress 146 89.04 High High
Parkinson's Disease 10 79.40 Quite High
Toxicity 1 47.52 Quite Low
Death 13 43.52 Quite Low
Alzheimer's Dementia 1 39.76 Quite Low
Neurodegenerative Disease 13 32.88 Quite Low
Aging 16 31.76 Quite Low
Lifespan 1 30.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The underlying hypothesis is that testosterone has a direct effect on transcription of the MAOA gene by acting on one of the promoters.
Transcription (transcription) of MAOA
1) Confidence 0.69 Published 2010 Journal Ann Gen Psychiatry Section Body Doc Link PMC2910031 Disease Relevance 0.34 Pain Relevance 0.24
The iron levels in this brain region are high, as is the activity of monoamine oxidase, and both of these entities contribute to the generation of ROS in these neurons.
Transcription (activity) of monoamine oxidase in neurons associated with monoamine
2) Confidence 0.22 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 0.88 Pain Relevance 0.18

General Comments

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