INT31156

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.42
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 1.83
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ptpn1) endoplasmic reticulum (Ptpn1) plasma membrane (Ptpn1)
Anatomy Link Frequency
liver 2
osteoblasts 1
Ptpn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 1 99.56 Very High Very High Very High
tetrodotoxin 1 97.68 Very High Very High Very High
dexamethasone 43 95.24 Very High Very High Very High
gABA 1 82.88 Quite High
cINOD 2 76.04 Quite High
Neurotransmitter 1 75.00 Quite High
Inflammation 4 46.76 Quite Low
withdrawal 7 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 110 98.48 Very High Very High Very High
Repression 1 95.76 Very High Very High Very High
Stress 65 94.24 High High
INFLAMMATION 5 75.52 Quite High
Toxicity 4 71.12 Quite High
Body Weight 8 66.32 Quite High
Hepatocellular Cancer 8 61.16 Quite High
Breast Cancer 1 60.60 Quite High
Targeted Disruption 5 50.12 Quite High
Congenital Anomalies 4 49.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PTP was markedly reduced by reserpine treatment or tissue incubation with prazosin.
Negative_regulation (reduced) of PTP
1) Confidence 0.42 Published 1987 Journal Neurosci. Lett. Section Abstract Doc Link 2883614 Disease Relevance 0 Pain Relevance 0.23
Based on our findings, we assume that the reduced activity of PTP1B could by an explanation for the lower triglyceride concentrations in livers of BSO-treated rats.
Negative_regulation (reduced) of PTP1B in livers
2) Confidence 0.28 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2881051 Disease Relevance 0.54 Pain Relevance 0
In active PTP1B, the catalytic cysteine Cys215 is reduced [21,22], whereas oxidation of Cys215 in the presence of mild oxidative conditions causes the reversible formation of a cyclic sulfenamide species and leads to the inhibition of enzyme activity [23,24].
Negative_regulation (reduced) of PTP1B
3) Confidence 0.21 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2881051 Disease Relevance 0.13 Pain Relevance 0
We assume that the reduced hepatic activity of the redox-sensitive PTP1B, the lower concentration of glutathionylated PTP1B and the higher concentration of irreversible oxidized PTP1B in the glutathione-depleted rats could explain, at least in part, the reduced levels of triglycerides in the liver of these animals.


Negative_regulation (reduced) of PTP1B in liver
4) Confidence 0.21 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2881051 Disease Relevance 0.22 Pain Relevance 0
The reduced activity of PTP1B and the higher concentration of irreversible oxidized PTP1B could be, at least in part, responsible for this effect.



Negative_regulation (reduced) of PTP1B
5) Confidence 0.21 Published 2010 Journal Lipids Health Dis Section Abstract Doc Link PMC2881051 Disease Relevance 0.09 Pain Relevance 0
The non-selective PTP inhibitor, vanadate, protected MBA-15.4 osteoblasts against apoptosis, induced by 6-h, 3-day and 6-day treatment with high-dose Dex.
Negative_regulation (inhibitor) of PTP in osteoblasts associated with apoptosis and dexamethasone
6) Confidence 0.11 Published 2007 Journal The Journal of Endocrinology Section Body Doc Link PMC2173947 Disease Relevance 0.85 Pain Relevance 0.20

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox