INT311613

Context Info Confidence 0.24 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.32 Pain Relevance 0.21

plasma membrane (Slc6a4, Pten) cytosol (Slc6a4) endosome (Slc6a4) mitochondrion (Pten) aging (Pten) nucleus (Pten)

Slc6a4 (Rattus norvegicus) Pten (Rattus norvegicus)

Pain Link Frequency Relevance Heat amygdala 5 88.36 Hippocampus 2 87.84 Pyramidal cell 1 78.72 Somatosensory cortex 1 76.76 Serotonin 11 50.00 cocaine 39 37.88 Dopamine 6 32.92 Eae 18 19.52 Cannabinoid receptor 3 17.12 Migraine 1 10.36

Disease Link Frequency Relevance Heat Macrocephaly 1 99.80 Anxiety Disorder 23 61.52 Adhesions 2 56.88 Apoptosis 3 51.84 Targeted Disruption 6 50.00 Sprains And Strains 13 49.44 Increased Venous Pressure Under Development 2 13.96 Headache 2 10.36 Obesity 30 5.00 Hypertension 7 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Of interest, a recent study found an epistatic interaction of Slc6a4 and Pten for macrocephaly in mice [39].

Slc6a4 Binding (interaction) of Pten associated with macrocephaly

1) Confidence 0.24 Published 2010 Journal BMC Genet Section Body Doc Link PMC2874760 Disease Relevance 0.32 Pain Relevance 0.21

General Comments

This test has worked.