INT31162

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Context Info
Confidence 0.78
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 7.38
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (SELL) plasma membrane (SELL)
Anatomy Link Frequency
Plasma 2
lymphocytes 2
brain 2
T-cell 2
neurons 1
SELL (Homo sapiens)
SELL - L8Y (1)
Pain Link Frequency Relevance Heat
Enkephalin 6 100.00 Very High Very High Very High
Neuropeptide 2 99.92 Very High Very High Very High
Somatostatin 2 99.16 Very High Very High Very High
metalloproteinase 3 98.24 Very High Very High Very High
medulla 3 97.96 Very High Very High Very High
chemokine 12 97.68 Very High Very High Very High
Inflammation 184 94.56 High High
rheumatoid arthritis 113 90.44 High High
Angina 3 75.00 Quite High
Inflammatory mediators 11 71.12 Quite High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 98.76 Very High Very High Very High
Adhesions 95 97.92 Very High Very High Very High
Pheochromocytoma 4 97.48 Very High Very High Very High
Celiac Disease 6 96.92 Very High Very High Very High
INFLAMMATION 229 94.56 High High
Cardiovascular Disease 33 93.76 High High
Brain Injury 144 91.40 High High
Rheumatoid Arthritis 125 90.44 High High
Disease 203 89.96 High High
Ganglion Cysts 8 88.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical studies for multiple peptide-immunoreactivities and co-localization of Met-enkephalin-Arg6-Gly7-Leu8, neuropeptide Y and somatostatin in human adrenal medulla and pheochromocytomas.
Localization (co-localization) of Leu8 in adrenal medulla associated with medulla, somatostatin, neuropeptide, enkephalin and pheochromocytoma
1) Confidence 0.78 Published 1987 Journal Peptides Section Title Doc Link 2883635 Disease Relevance 0.43 Pain Relevance 0.49
Brief treatment of human peripheral blood lymphocytes with the potential anti-HIV compound aurintricarboxylic acid (ATA) prompts the selective release of already bound L-selectin-specific anti-Leu8 and anti-LAM1-1 antibodies from the cells.
Localization (release) of L-selectin in lymphocytes associated with acquired immune deficiency syndrome or hiv infection
2) Confidence 0.78 Published 1993 Journal Mol. Immunol. Section Abstract Doc Link 7505884 Disease Relevance 0.10 Pain Relevance 0
Immunohistochemical colocalization of Met5-enkephalin-Arg6-Gly7-Leu8 with tyrosine hydroxylase in neurons of the porcine inferior mesenteric and coeliac-superior mesenteric ganglia.
Localization (colocalization) of Leu8 (L8Y) in neurons associated with celiac disease and enkephalin
3) Confidence 0.78 Published 1994 Journal Folia Histochem. Cytobiol. Section Title Doc Link 7758615 Disease Relevance 0.48 Pain Relevance 0.19
The localization and distribution of the proenkephalin A-derived octapeptide Met5-enkephalin-Arg6-Gly7-Leu8 (MEAGL) was studied in the porcine sympathetic prevertebral ganglia by using the indirect immunofluorescence technique.
Localization (localization) of Leu8 in prevertebral ganglia associated with enkephalin
4) Confidence 0.68 Published 1994 Journal Folia Histochem. Cytobiol. Section Abstract Doc Link 7758615 Disease Relevance 0.42 Pain Relevance 0.17
After conventional crystalloid resuscitation, we found that relative to healthy controls, brain-injured patients exhibit extensive leukocyte mobilization, with significantly enhanced PMN and monocyte surface expression of L-selectin (CD62L) and ?
Localization (mobilization) of L-selectin in brain
5) Confidence 0.65 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 1.27 Pain Relevance 0.06
After conventional crystalloid resuscitation, we found that relative to healthy controls, brain-injured patients exhibit extensive leukocyte mobilization, with significantly enhanced PMN and monocyte surface expression of L-selectin (CD62L) and ?
Localization (mobilization) of CD62L in brain
6) Confidence 0.65 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 1.28 Pain Relevance 0.06
Brief treatment of human peripheral blood lymphocytes with the potential anti-HIV compound aurintricarboxylic acid (ATA) prompts the selective release of already bound L-selectin-specific anti-Leu8 and anti-LAM1-1 antibodies from the cells.
Localization (release) of anti-Leu8 in lymphocytes associated with acquired immune deficiency syndrome or hiv infection
7) Confidence 0.39 Published 1993 Journal Mol. Immunol. Section Abstract Doc Link 7505884 Disease Relevance 0.10 Pain Relevance 0
Plasma profiling of SJIA flare and quiescent samples using this antibody array identified a biomarker panel of TIMP1, IL-18, RANTES, P-Selectin, MMP9, and L-Selectin, all of which are present at higher abundance in SJIA flare than in quiescence.
Localization (panel) of L-Selectin in Plasma
8) Confidence 0.29 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 0.72 Pain Relevance 0.25
The antibody array plasma profiling identified an SJIA plasma flare signature consisting of tissue inhibitor of metalloproteinase-1 (TIMP1), interleukin (IL)-18, regulated upon activation, normal T cell expressed and secreted (RANTES), P-Selectin, MMP9, and L-Selectin.


Localization (secreted) of L-Selectin in T cell associated with metalloproteinase
9) Confidence 0.27 Published 2010 Journal Clin Proteomics Section Abstract Doc Link PMC2970804 Disease Relevance 0.72 Pain Relevance 0.15
Identification of TIMP1, IL18, RANTES, P-Selectin, MMP9, and L-Selectin as SJIA Plasma Flare Biomarkers
Localization (Identification) of L-Selectin in Plasma
10) Confidence 0.13 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 0.49 Pain Relevance 0.17
We measured and compared the ratio of elevated levels of regulated on activation normally T-cell expressed and secreted (RANTES), monocytic chemotactic peptide-1 (MCP-1), soluble (s) P-selectin and sL-selectin after PCI.
Localization (secreted) of sL-selectin in T-cell
11) Confidence 0.01 Published 2006 Journal Platelets Section Abstract Doc Link 17127484 Disease Relevance 0.61 Pain Relevance 0.21
Regarding endothelial biomarkers, IMT was significantly related to tPA-mass, VWF, sL-selectin and MCP-1 and ED-FMD was significantly related to PAI-1 and sL-selectin (Table 4).
Localization (sL-selectin) of sL-selectin
12) Confidence 0.00 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945061 Disease Relevance 0.77 Pain Relevance 0.19

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