INT311626

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Context Info
Confidence 0.34
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.29
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Tfap2a) Golgi apparatus (Tfap2a) nucleus (Tfap2a)
DNA binding (Tfap2a) transcription factor binding (Tfap2a) cytoplasm (Tfap2a)
Anatomy Link Frequency
embryos 2
Tfap2a (Mus musculus)
Pain Link Frequency Relevance Heat
midbrain 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
vagus nerve 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 27 99.24 Very High Very High Very High
Apoptosis 19 96.48 Very High Very High Very High
Cleft Palate 8 91.48 High High
Congenital Anomalies 7 5.00 Very Low Very Low Very Low
Persistent Truncus Arteriosus 4 5.00 Very Low Very Low Very Low
Ventricular Heart Septal Defects 4 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low
Syndrome 1 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Polydactyly 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the domains of expression of several key transcription factors important to normal craniofacial and cardiac development including AP2, Msx2, Dlx5, and Dlx6 were reduced in Spry1;Wnt1-Cre transgenic embryos.


Negative_regulation (reduced) of Gene_expression (expression) of AP2 in embryos associated with targeted disruption
1) Confidence 0.34 Published 2010 Journal BMC Dev Biol Section Abstract Doc Link PMC2874773 Disease Relevance 0.29 Pain Relevance 0

General Comments

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