INT311638

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Context Info
Confidence 0.72
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 48
Disease Relevance 16.38
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Spry1)
Anatomy Link Frequency
embryos 12
neural crest 8
neural crest cells 4
limb buds 3
cranial nerves 2
Spry1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 96 99.60 Very High Very High Very High
midbrain 96 94.92 High High
vagus nerve 48 94.16 High High
anesthesia 96 7.92 Low Low
isoflurane 48 6.32 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 1296 100.00 Very High Very High Very High
Apoptosis 912 99.78 Very High Very High Very High
Sprains And Strains 48 96.88 Very High Very High Very High
Congenital Anomalies 336 96.84 Very High Very High Very High
Ventricular Heart Septal Defects 192 95.64 Very High Very High Very High
Persistent Truncus Arteriosus 192 94.72 High High
Cleft Palate 384 87.60 High High
Patent Ductus Arteriosus 48 85.52 High High
Polydactyly 48 84.24 Quite High
Dwarfism 48 73.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our study shows that Spry1 expression in Wnt1-expressing neural crest cells in vivo results in facial clefting, cleft plate, failure of formation of the nasal and frontal bones as well as cardiovascular defects including ventricular septal defects, and outflow tract defects.
Gene_expression (expression) of Spry1 in nasal associated with ventricular heart septal defects
1) Confidence 0.72 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.79 Pain Relevance 0
Forced expression of Spry1 in Wnt1-expressing cells was also associated with defects in the development of cranial nerves including the glossopharyngeal nerve (IX) and the vagus nerve (X).
Gene_expression (expression) of Spry1 in cranial nerves associated with vagus nerve
2) Confidence 0.72 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.37 Pain Relevance 0.05
Conditional expression Spry1 inhibits proliferation and increases apoptosis in neural crest and neural crest-derived structures
Gene_expression (expression) of Spry1 in neural crest associated with apoptosis
3) Confidence 0.72 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.18 Pain Relevance 0
In situ hybridization analysis at E8.0 revealed that Spry1 is highly expressed in the cranial neural folds and presomitic mesoderm (Figure 1A) and continues to be expressed in regions populated by cells of neural crest origin including the branchial arches 1, 2, and 3, the frontonasal process, the midbrain hindbrain boundary, as well as limb buds and presomitic mesoderm at E9.0 (Figure 1C).
Gene_expression (expressed) of Spry1 in presomitic mesoderm associated with midbrain
4) Confidence 0.72 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.28 Pain Relevance 0.05
To determine the effect of conditional expression of Spry1 in Wnt1-Cre expressing cells on cranial nerve morphogenesis, E10.5 Spry1;Wnt1-Cre embryos were immunostained with a neurofilament-M antibody.
Gene_expression (expression) of Spry1 in embryos
5) Confidence 0.72 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.09 Pain Relevance 0.04
In situ hybridization analysis at E8.0 revealed that Spry1 is highly expressed in the cranial neural folds and presomitic mesoderm (Figure 1A) and continues to be expressed in regions populated by cells of neural crest origin including the branchial arches 1, 2, and 3, the frontonasal process, the midbrain hindbrain boundary, as well as limb buds and presomitic mesoderm at E9.0 (Figure 1C).
Gene_expression (expressed) of Spry1 in presomitic mesoderm associated with midbrain
6) Confidence 0.72 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.28 Pain Relevance 0.05
Spry1 expression in NCC cells resulted in decreased proliferation and increased apoptosis.
Gene_expression (expression) of Spry1 associated with apoptosis
7) Confidence 0.72 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.66 Pain Relevance 0
To over express Spry1 in neural crest cells CAGGFP-Spry1 mice were crossed with Wnt1-Cre mice, and double transgenic mice were identified by PCR of genomic DNA from either tails or placenta using specific primer for GFP and Cre.
Gene_expression (express) of Spry1 in neural crest cells associated with targeted disruption
8) Confidence 0.72 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.48 Pain Relevance 0
However, we have previously demonstrated Spry1 transgenic protein expression using the same transgenic mice when crossed with other transgenic Cre driver strains [21]. qPCR analysis revealed expression levels of the transgene to be 2-8 fold above endogenous expression levels (Yang, data not shown).


Gene_expression (expression) of Spry1 associated with targeted disruption and sprains and strains
9) Confidence 0.72 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.79 Pain Relevance 0
To investigate the role of Spry1 in regulating NCC during development, we induced tissue-specific expression of Spry1 using Cre/loxP recombination in the neural crest lineage by using Wnt1-Cre transgenic mice [20].
Gene_expression (expression) of Spry1 in neural crest associated with targeted disruption
10) Confidence 0.72 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.80 Pain Relevance 0
Our data indicate that forced expression of Spry1 in Wnt1-Cre expressing cells results in reduced domains of Msx1 and Msx2 expression in craniofacial structures, while expression in the limb buds remains intact albeit at a reduced level.
Gene_expression (expression) of Spry1 in limb buds
11) Confidence 0.72 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.14 Pain Relevance 0
To gain additional insight into the pattern of embryonic Spry1 expression, we performed ?
Gene_expression (expression) of Spry1
12) Confidence 0.72 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.18 Pain Relevance 0.04
Conditional expression of Spry1 inhibits palatogenesis
Gene_expression (expression) of Spry1
13) Confidence 0.72 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.15 Pain Relevance 0
Spry1 is expressed in migrating and post-migratory neural crest cells
Gene_expression (expressed) of Spry1 in neural crest cells
14) Confidence 0.72 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.42 Pain Relevance 0.03
Conditional expression of Spry1 in neural crest cells
Gene_expression (expression) of Spry1 in neural crest cells
15) Confidence 0.72 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.26 Pain Relevance 0.04
We examined the expression Spry1 in mouse embryos from E8.0 to E10.0 using whole-mount in situ hybridization.
Spec (examined) Gene_expression (expression) of Spry1 in embryos
16) Confidence 0.62 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.35 Pain Relevance 0.03
-gal staining (Figure 4A-D) and sections (Figure 4E-H) through E10.5 Spry1;R26R;Wnt1-Cre embryos revealed ?
Gene_expression (staining) of Spry1 in embryos
17) Confidence 0.62 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.18 Pain Relevance 0
Spry1;Wnt1-Cre embryos have cranial nerve patterning defects
Gene_expression (embryos) of Spry1;Wnt1-Cre in patterning
18) Confidence 0.62 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.13 Pain Relevance 0.04
Here we show that Spry1 over expression in neural crest derivatives partially phenocopies the palate defect of the Pub36-/- mutation.
Gene_expression (expression) of Spry1 in palate
19) Confidence 0.62 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.31 Pain Relevance 0
Because fgf8 expression was essentially normal in Spry1;Wnt1-Cre embryos, fgf8 availability is likely not a factor in decreased NCC survival.
Gene_expression (embryos) of Spry1;Wnt1-Cre in embryos
20) Confidence 0.62 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.40 Pain Relevance 0

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