INT311645

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Context Info
Confidence 0.70
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.81
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Spry2) cytoskeleton (Spry2) cytoplasm (Spry2)
Anatomy Link Frequency
palate 3
inner ear 1
Spry2 (Mus musculus)
Pain Link Frequency Relevance Heat
midbrain 8 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
vagus nerve 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 108 99.88 Very High Very High Very High
Cleft Palate 32 98.24 Very High Very High Very High
Congenital Anomalies 28 95.76 Very High Very High Very High
Dwarfism 4 87.68 High High
Polydactyly 4 82.56 Quite High
Apoptosis 76 58.08 Quite High
Persistent Truncus Arteriosus 16 46.88 Quite Low
Ventricular Heart Septal Defects 16 46.72 Quite Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low
Syndrome 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, targeted disruption of Spry2 did not phenocopy the megabase deletion in chromosome 14; however a BAC Spry2 transgene expressing reduced levels of Spry2 completely rescued the facial clefting and cleft palate phenotype in Pub36-/- mice [19].
Gene_expression (expressing) of Spry2 in palate associated with targeted disruption and cleft palate
1) Confidence 0.70 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.43 Pain Relevance 0
Interestingly, targeted disruption of Spry2 did not phenocopy the megabase deletion in chromosome 14; however a BAC Spry2 transgene expressing reduced levels of Spry2 completely rescued the facial clefting and cleft palate phenotype in Pub36-/- mice [19].
Gene_expression (expressing) of Spry2 in palate associated with targeted disruption and cleft palate
2) Confidence 0.70 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.43 Pain Relevance 0
However, the Spry2-BAC transgenic line expressed Spry2 at reduced levels suggesting that palate development is Spry2 dosage sensitive [19].
Gene_expression (expressed) of Spry2 in palate associated with targeted disruption
3) Confidence 0.61 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.70 Pain Relevance 0
Previous studies using gene-targeting strategies revealed that targeted deletion of Spry1 [17] did not produce a craniofacial phenotype, and deletion of Spry2 produced defects in the inner ear [15] and dentition [16], however deletion of Spry2 and Spry4 results in several abnormalities including facial clefting and limb defects [18].
Gene_expression (produced) of Spry2 in inner ear associated with congenital anomalies
4) Confidence 0.54 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.25 Pain Relevance 0

General Comments

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