INT311661

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Context Info
Confidence 0.30
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.44
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Slc12a3) transport (Slc12a3) plasma membrane (Slc12a3)
transmembrane transport (Slc12a3) cytoplasm (Spry1)
Anatomy Link Frequency
neural crest 1
mesodermal cells 1
Spry1 (Mus musculus)
Slc12a3 (Mus musculus)
Pain Link Frequency Relevance Heat
midbrain 4 48.40 Quite Low
anesthesia 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
vagus nerve 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 38 99.24 Very High Very High Very High
Targeted Disruption 54 98.84 Very High Very High Very High
Ventricular Heart Septal Defects 8 91.32 High High
Cleft Palate 16 87.20 High High
Dwarfism 2 76.80 Quite High
Polydactyly 2 71.68 Quite High
Congenital Anomalies 14 7.64 Low Low
Persistent Truncus Arteriosus 8 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Syndrome 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that Spry1 is a regulator of NCC cell proliferation and survival and that this occurs in both NCC cells and NCC-derived mesodermal cells that result in craniofacial and cardiac structures.


Spry1 Regulation (regulator) of NCC in mesodermal cells
1) Confidence 0.30 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.63 Pain Relevance 0
To investigate the role of Spry1 in regulating NCC during development, we induced tissue-specific expression of Spry1 using Cre/loxP recombination in the neural crest lineage by using Wnt1-Cre transgenic mice [20].
Spry1 Spec (investigate) Regulation (regulating) of NCC in neural crest associated with targeted disruption
2) Confidence 0.22 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.80 Pain Relevance 0

General Comments

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