INT3117

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Context Info
Confidence 0.61
First Reported 1975
Last Reported 2010
Negated 21
Speculated 10
Reported most in Title
Documents 103
Total Number 113
Disease Relevance 17.93
Pain Relevance 32.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Oxt) extracellular region (Oxt) cytoplasm (Oxt)
Anatomy Link Frequency
uterine 19
plasma 15
CSF 4
myometrium 3
terminal portion 2
Oxt (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 156 100.00 Very High Very High Very High
antagonist 61 100.00 Very High Very High Very High
Morphine 48 100.00 Very High Very High Very High
Opioid 46 100.00 Very High Very High Very High
analgesia 24 100.00 Very High Very High Very High
epidural 24 100.00 Very High Very High Very High
opiate 24 100.00 Very High Very High Very High
Dopamine 16 100.00 Very High Very High Very High
Analgesic 12 100.00 Very High Very High Very High
Enkephalin 12 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 44 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 10 100.00 Very High Very High Very High
Rupture 4 100.00 Very High Very High Very High
Acidosis 1 100.00 Very High Very High Very High
Hypoglycemia 24 99.84 Very High Very High Very High
INFLAMMATION 108 99.78 Very High Very High Very High
Targeted Disruption 19 99.60 Very High Very High Very High
Dysmenorrhea 76 99.56 Very High Very High Very High
Pain 14 99.40 Very High Very High Very High
Asthma 241 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of nipple stimulation on uterine activity, foetal heart rate and plasma oxytocin level in healthy full term pregnant women was studied.
Regulation (effect) of oxytocin in nipple
1) Confidence 0.61 Published 1989 Journal Acta Obstet Gynecol Scand Section Abstract Doc Link 2618602 Disease Relevance 0.17 Pain Relevance 0.09
Effect of nipple stimulation on uterine activity and on plasma levels of oxytocin in full term, healthy, pregnant women.
Regulation (Effect) of oxytocin in uterine
2) Confidence 0.61 Published 1989 Journal Acta Obstet Gynecol Scand Section Title Doc Link 2618602 Disease Relevance 0.17 Pain Relevance 0.09
Ritodrine, on the other hand, had no significant effect on circulating oxytocin levels.
Neg (no) Regulation (effect) of oxytocin
3) Confidence 0.60 Published 1982 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 7148897 Disease Relevance 0.41 Pain Relevance 0.07
Influence of oxytocin or epidural analgesia on personality profile in breastfeeding women: a comparative study.
Regulation (Influence) of oxytocin associated with epidural and analgesia
4) Confidence 0.58 Published 2008 Journal Arch Womens Ment Health Section Title Doc Link 18726143 Disease Relevance 0.19 Pain Relevance 0.37
Naloxone did not alter the proportion of occasions in which females showed an oxytocin response, nor did it have a significant effect on the levels of oxytocin achieved during coitus in either the male or the female rabbits.
Regulation (response) of oxytocin associated with narcan
5) Confidence 0.55 Published 1986 Journal Psychoneuroendocrinology Section Abstract Doc Link 3024195 Disease Relevance 0 Pain Relevance 0.20
In contrast, SON lesions did not alter basal oxytocin levels and did not reduce the oxytocin response to p-chloroamphetamine, suggesting that the SON is not involved in the serotonergic stimulation of oxytocin secretion.
Neg (not) Regulation (alter) of oxytocin
6) Confidence 0.52 Published 1995 Journal Brain Res. Bull. Section Abstract Doc Link 7882048 Disease Relevance 0 Pain Relevance 0.08
Effect of an oxytocin antagonist on plasma oxytocin levels during nocturnal uterine contractions in the pregnant baboon.
Regulation (Effect) of oxytocin in uterine associated with antagonist and dismenorea
7) Confidence 0.50 Published 2002 Journal Gynecol. Endocrinol. Section Title Doc Link 12192888 Disease Relevance 0.26 Pain Relevance 0.43
Most studies that attempt to elucidate the transcriptional regulation of oxytocin receptors have been performed in myometrial and uterine cells.
Regulation (regulation) of oxytocin in uterine
8) Confidence 0.48 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0.69 Pain Relevance 0.30
Age, sex, percent predicted forced expiratory volume in one second, and inhaled corticosteroid dose were added into the model with disease state one at a time to determine if they altered the effect of disease on oxytocin levels.


Regulation (altered) of oxytocin associated with corticosteroid and disease
9) Confidence 0.48 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0.28 Pain Relevance 0.09
Effects of oxytocin and a derivative (Z-prolyl-D-leucine) on morphine tolerance/withdrawal are mediated by the limbic system.
Regulation (Effects) of oxytocin associated with tolerance, limbic system, withdrawal and morphine
10) Confidence 0.45 Published 1984 Journal Behav. Brain Res. Section Title Doc Link 6542796 Disease Relevance 0 Pain Relevance 0.84
The effects of oxytocin (OXT) and of dipeptides derived from the C-terminal portion of oxytocin (Z-prolyl-leucine and Z-prolyl-D-leucine) on the development of acute and chronic tolerance to, and dependence on morphine were tested in the mouse.
Regulation (effects) of oxytocin in terminal portion associated with addiction, tolerance and morphine
11) Confidence 0.45 Published 1985 Journal Neuropharmacology Section Abstract Doc Link 2991800 Disease Relevance 0.07 Pain Relevance 0.61
The importance of oxytocin mechanisms in the control of mouse parturition.
Regulation (importance) of oxytocin associated with narcan
12) Confidence 0.45 Published 2002 Journal Reproduction Section Title Doc Link 11914117 Disease Relevance 0.12 Pain Relevance 0.15
[Influence of oxytocin and prostaglandin E2 on icterus neonatorum (author's transl)].
Regulation ([Influence) of oxytocin associated with newborn jaundice
13) Confidence 0.45 Published 1981 Journal Geburtshilfe Frauenheilkd Section Title Doc Link 7215766 Disease Relevance 0.28 Pain Relevance 0.18
Oxytocin administration during the block did not affect fetal heart rate or uterine activity.
Neg (not) Regulation (affect) of Oxytocin in uterine
14) Confidence 0.44 Published 1987 Journal Clin Exp Obstet Gynecol Section Abstract Doc Link 3815837 Disease Relevance 0.51 Pain Relevance 0.32
We propose that fetal and maternal stress/pain after surgery may affect the concentration of circulating oxytocin and the frequency of uterine contractions, thus increasing the risk of preterm delivery.
Spec (may) Regulation (affect) of oxytocin in uterine associated with stress, pain, premature birth and dismenorea
15) Confidence 0.44 Published 2006 Journal J. Matern. Fetal. Neonatal. Med. Section Abstract Doc Link 16854697 Disease Relevance 0.47 Pain Relevance 0.52
RESULTS: Plasma oxytocin concentration did not change significantly after cerclage in either group.
Neg (not) Regulation (change) of oxytocin in Plasma
16) Confidence 0.44 Published 2008 Journal Int J Obstet Anesth Section Body Doc Link 17698336 Disease Relevance 0 Pain Relevance 0
The effect of continuous morphine administration on maternal plasma oxytocin concentration and uterine contractions after open fetal surgery.
Regulation (effect) of oxytocin in uterine associated with dismenorea and morphine
17) Confidence 0.44 Published 2006 Journal J. Matern. Fetal. Neonatal. Med. Section Title Doc Link 16854697 Disease Relevance 0.46 Pain Relevance 0.55
CONCLUSIONS: Anesthetic method used for elective Shirodkar procedure did not affect the perioperative changes in plasma oxytocin nor postoperative uterine activity.


Neg (nor) Regulation (affect) of oxytocin in uterine
18) Confidence 0.44 Published 2008 Journal Int J Obstet Anesth Section Body Doc Link 17698336 Disease Relevance 0 Pain Relevance 0
Pulsatile oxytocin for induction of labor: a randomized prospective controlled study.
Regulation (controlled) of oxytocin
19) Confidence 0.44 Published 1988 Journal J Perinat Med Section Title Doc Link 3404378 Disease Relevance 0.09 Pain Relevance 0.09
The effect of RU 486, a steroid acting as an antiprogestin at the receptor level, on uterine contractility and sensitivity to the prostaglandin analogue, 16-phenoxy-PGE2 methyl sulfonylamide (16-phenoxy-PGE2) and to oxytocin was studied in 29 women in early pregnancy.
Regulation (effect) of oxytocin in uterine
20) Confidence 0.44 Published 1988 Journal Br J Obstet Gynaecol Section Abstract Doc Link 3349002 Disease Relevance 0.07 Pain Relevance 0.09

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