INT311726

Context Info Confidence 0.09 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.60 Pain Relevance 0.04

extracellular space (Plat, Sele) molecular_function (Plat, Sele) peptidase activity (Plat) extracellular region (Plat) cell adhesion (Sele) cellular_component (Sele)

Anatomy Link Frequency immune cells 2 Plat (Rattus norvegicus) Sele (Rattus norvegicus)

Pain Link Frequency Relevance Heat Inflammation 2 70.16 metalloproteinase 1 46.96 cva 2 25.92 ischemia 6 5.00 anesthesia 5 5.00 isoflurane 3 5.00 corticosteroid 1 5.00 aspirin 1 5.00 Inflammatory response 1 5.00 Glutamate 1 5.00

Disease Link Frequency Relevance Heat Adhesions 2 100.00 Stroke 57 86.48 INFLAMMATION 3 70.16 Middle Cerebral Artery Infarction 31 69.80 Pressure And Volume Under Development 2 26.44 Cv General 3 Under Development 1 25.92 Hemorrhage 1 14.52 Injury 6 5.00 Death 3 5.00 Cv General 4 Under Development 3 5.00

Sentences Mentioned In

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Protein

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Event

Anatomy

Negation

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Disease term

Indirectly tPA modulates immune cells that interact with endothelium. tPA increases endothelial adhesion molecule expression including ICAM2, P-Selectin, and E-Selectin [20,21].

tPA Positive_regulation (increases) of Gene_expression (expression) of E-Selectin in immune cells associated with adhesions

1) Confidence 0.09 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2875237 Disease Relevance 0.60 Pain Relevance 0.04

General Comments

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