INT311777

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Context Info
Confidence 0.16
First Reported 2010
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 4.43
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (MID1) ligase activity (MID1) cytoplasm (MID1)
Anatomy Link Frequency
brain 2
neurons 1
pericytes 1
astrocytes 1
MID1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 30 99.82 Very High Very High Very High
Central nervous system 36 97.84 Very High Very High Very High
Neurotransmitter 8 81.12 Quite High
Glutamate 4 64.72 Quite High
Inflammatory stimuli 2 38.60 Quite Low
Inflammatory mediators 4 30.64 Quite Low
bradykinin 4 27.28 Quite Low
substance P 4 26.00 Quite Low
metalloproteinase 4 8.40 Low Low
imagery 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 44 99.82 Very High Very High Very High
Metastasis 304 99.08 Very High Very High Very High
Cancer 330 98.64 Very High Very High Very High
Breast Cancer 168 97.72 Very High Very High Very High
Sepsis 46 90.04 High High
Encephalopathy 28 83.48 Quite High
Adhesions 44 82.48 Quite High
Acute Liver Failure 2 74.32 Quite High
Apoptosis 4 68.80 Quite High
Injury 8 68.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, if it is assumed that the kinetic constants for phenylalanine transfer across the BBB are not affected by the LPS challenge, the present study provides direct evidence that links the alterations in the BCAA/AAA ratio with changes in the brain's amino acid content in the context of systemic inflammation.
Neg (not) Regulation (affected) of BBB in brain associated with inflammation
1) Confidence 0.16 Published 2010 Journal Crit Care Section Body Doc Link PMC2875531 Disease Relevance 0.64 Pain Relevance 0.11
Conversely, the observed changes could be caused by inflammation-induced alterations in BBB function.
Regulation (alterations) of BBB associated with inflammation
2) Confidence 0.07 Published 2010 Journal Crit Care Section Body Doc Link PMC2875531 Disease Relevance 0.73 Pain Relevance 0.20
Interactions between the brain endothelium, astrocytes, and neurons may also regulate blood-brain barrier (BBB) function [36].
Spec (may) Regulation (regulate) of BBB in brain
3) Confidence 0.01 Published 2011 Journal Pathology Research International Section Body Doc Link PMC3021881 Disease Relevance 1.17 Pain Relevance 0
The BBB, a regulated interface between the peripheral circulation and the central nervous system (CNS), is comprised of the cerebral microvascular endothelium, which together with neurons, astrocytes, pericytes, and the extracellular matrix, constitute a “neurovascular unit” (Figure 1) [3, 4, 6].
Regulation (regulated) of BBB in astrocytes associated with central nervous system
4) Confidence 0.01 Published 2011 Journal Pathology Research International Section Body Doc Link PMC3021881 Disease Relevance 0.63 Pain Relevance 0.10
The BBB, a regulated interface between the peripheral circulation and the central nervous system (CNS), is comprised of the cerebral microvascular endothelium, which together with neurons, astrocytes, pericytes, and the extracellular matrix, constitute a “neurovascular unit” (Figure 1) [3, 4, 6].
Regulation (regulated) of BBB in neurons associated with central nervous system
5) Confidence 0.00 Published 2011 Journal Pathology Research International Section Body Doc Link PMC3021881 Disease Relevance 0.63 Pain Relevance 0.10
The BBB, a regulated interface between the peripheral circulation and the central nervous system (CNS), is comprised of the cerebral microvascular endothelium, which together with neurons, astrocytes, pericytes, and the extracellular matrix, constitute a “neurovascular unit” (Figure 1) [3, 4, 6].
Regulation (regulated) of BBB in pericytes associated with central nervous system
6) Confidence 0.00 Published 2011 Journal Pathology Research International Section Body Doc Link PMC3021881 Disease Relevance 0.63 Pain Relevance 0.10

General Comments

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