INT3118

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Context Info
Confidence 0.59
First Reported 1978
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 33
Total Number 34
Disease Relevance 9.42
Pain Relevance 18.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (POMC) cell-cell signaling (POMC) cytoplasm (POMC)
extracellular space (POMC) generation of precursor metabolites and energy (POMC) signal transduction (POMC)
Anatomy Link Frequency
plasma 18
hypothalamus 2
cerebrospinal fluid 2
pituitary 2
PVN 2
POMC (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 34 100.00 Very High Very High Very High
Enkephalin 26 100.00 Very High Very High Very High
narcan 22 100.00 Very High Very High Very High
cocaine 7 100.00 Very High Very High Very High
Catecholamine 7 100.00 Very High Very High Very High
cva 6 100.00 Very High Very High Very High
Pain 4 100.00 Very High Very High Very High
agonist 21 99.96 Very High Very High Very High
headache 10 99.96 Very High Very High Very High
Morphine 38 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 90 100.00 Very High Very High Very High
Cv General 3 Under Development 6 100.00 Very High Very High Very High
Pain 6 100.00 Very High Very High Very High
Headache 2 99.96 Very High Very High Very High
Depression 2 99.02 Very High Very High Very High
Metastasis 1 98.36 Very High Very High Very High
Hypoglycemia 3 97.76 Very High Very High Very High
Heart Rate Under Development 2 97.68 Very High Very High Very High
Migraine Without Aura 5 96.16 Very High Very High Very High
Headache Disorders 5 94.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The decrease in SBP was associated with a decrease in plasma catecholamines and increase in beta-endorphin, whereas the increase in SBP was accompanied by an increase in catecholamine and Met-enkephalin levels.
Negative_regulation (decrease) of Positive_regulation (increase) of beta-endorphin in plasma associated with catecholamine and enkephalin
1) Confidence 0.59 Published 2000 Journal Peptides Section Abstract Doc Link 11035209 Disease Relevance 0.35 Pain Relevance 0.44
Prenatal morphine exposure suppressed the restraint stress-induced ACTH levels in both diestrus and proestrus females, but did not have any effects on the basal or stress-induced CORT levels.
Negative_regulation (suppressed) of Neg (not) Positive_regulation (induced) of ACTH associated with stress and morphine
2) Confidence 0.58 Published 2004 Journal Neuroendocrinology Section Abstract Doc Link 15583475 Disease Relevance 0.68 Pain Relevance 0.72
The stress-induced increase in the ACTH level was suppressed only by the highest dose of DEX (1.0 mg/kg) in both saline- and morphine-exposed, diestrus and proestrus females.
Negative_regulation (suppressed) of Positive_regulation (increase) of ACTH associated with stress, dexamethasone and morphine
3) Confidence 0.58 Published 2004 Journal Neuroendocrinology Section Abstract Doc Link 15583475 Disease Relevance 0.70 Pain Relevance 0.86
An opioid mixed agonist-antagonist, buprenorphine (4 mg/day sublingually), suppressed the acute cocaine-induced stimulation of both ACTH and euphoria.
Negative_regulation (suppressed) of Positive_regulation (stimulation) of ACTH associated with antagonist, agonist, opioid, cocaine and buprenorphine
4) Confidence 0.43 Published 1992 Journal Neuropsychopharmacology Section Abstract Doc Link 1329800 Disease Relevance 0 Pain Relevance 0.78
After the combined pituitary stimulation test (100 micrograms human CRH, 100 micrograms GnRH, 100 micrograms GH-releasing hormone, and 200 micrograms TRH), the ACTH peak (maximum increase at 30 min) was significantly blunted by loperamide from 9 +/- 1 to 4 +/- 1 pmol/L (P less than 0.001) and the area under the curve of ACTH from 0-120 min was reduced from 35 +/- 5 to 23 +/- 4 pmol/L.2 h (P less than 0.05).
Negative_regulation (reduced) of Positive_regulation (increase) of ACTH in pituitary
5) Confidence 0.43 Published 1992 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1322429 Disease Relevance 0.40 Pain Relevance 0.10
DEX pretreatment dose dependently suppressed the restraint stress-induced increased plasma ACTH concentration.
Negative_regulation (suppressed) of Positive_regulation (increased) of ACTH in plasma associated with stress and dexamethasone
6) Confidence 0.43 Published 2003 Journal Neuroendocrinology Section Abstract Doc Link 14688444 Disease Relevance 1.00 Pain Relevance 0.75
Absence of the normal increase of beta-endorphin and ACTH after sauna; 3.
Negative_regulation (Absence) of Positive_regulation (increase) of ACTH
7) Confidence 0.43 Published 1989 Journal Acta Endocrinol. Section Abstract Doc Link 2552728 Disease Relevance 0.26 Pain Relevance 0.09
In four manic-depressive patients, serial samples of cerebrospinal fluid revealed elevated endorphin levels, particularly Fraction I during the manic stage.
Negative_regulation (revealed) of Positive_regulation (elevated) of endorphin in cerebrospinal fluid associated with depression
8) Confidence 0.43 Published 1978 Journal Acta Psychiatr Scand Section Abstract Doc Link 636907 Disease Relevance 0.57 Pain Relevance 0.07
In humans, the opioid antagonist, naloxone, stimulates the release of CRH, and so of ACTH and cortisol, while alprazolam, an indirect GABAA agonist, blocks naloxone-induced ACTH and cortisol secretion.
Negative_regulation (blocks) of Positive_regulation (naloxone-induced) of ACTH associated with antagonist, agonist, narcan and opioid
9) Confidence 0.43 Published 1995 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 8582096 Disease Relevance 0 Pain Relevance 0.62
In normal subjects, the hCRH-induced ACTH, beta-endorphin, and cortisol increases were almost completely abolished by pretreatment with FK 33-824.
Negative_regulation (abolished) of Positive_regulation (increases) of ACTH
10) Confidence 0.42 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3023423 Disease Relevance 0.50 Pain Relevance 0.30
In normal subjects, the hCRH-induced ACTH, beta-endorphin, and cortisol increases were almost completely abolished by pretreatment with FK 33-824.
Negative_regulation (abolished) of Positive_regulation (increases) of beta-endorphin
11) Confidence 0.42 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3023423 Disease Relevance 0.50 Pain Relevance 0.30
In rat, the serotonin receptor antagonist metergoline decreased basal concentrations of the opioid peptide and blocked the increase of beta-endorphin concentrations induced by the serotonin precursor 5-hydroxytryptophan and the tricyclic antidepressant chlorimipramine.
Negative_regulation (blocked) of Positive_regulation (increase) of beta-endorphin associated with antagonist, tricyclic antidepressant, opioid and serotonin
12) Confidence 0.41 Published 1990 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 2143059 Disease Relevance 0 Pain Relevance 0.68
This abolished the increase in ACTH caused by naloxone or by the kappa-agonist.
Negative_regulation (abolished) of Positive_regulation (increase) of ACTH associated with agonist and narcan
13) Confidence 0.41 Published 1987 Journal Brain Res. Section Abstract Doc Link 2825911 Disease Relevance 0 Pain Relevance 1.43
Hypophysectomy did not affect either the magnitude of the increase or the pattern of change in pain threshold despite the resulting decrease in stress-induced plasma beta-endorphin concentrations.
Negative_regulation (decrease) of Positive_regulation (stress-induced) of beta-endorphin in plasma associated with stress and pain threshold
14) Confidence 0.41 Published 1987 Journal Brain Res. Section Abstract Doc Link 2959351 Disease Relevance 0.45 Pain Relevance 0.56
Naltrexone alone produced increases in plasma ACTH that were attenuated by the subsequent administration of noncontingent or response-contingent ethanol.
Negative_regulation (attenuated) of Positive_regulation (increases) of ACTH in plasma
15) Confidence 0.40 Published 2004 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 15100607 Disease Relevance 0 Pain Relevance 0
Treatment with the dopamine agonists bromocriptine or apomorphine had no effect, but haloperidol treatment increased anterior pituitary Met-enkephalin which was reversed by concomitant bromocriptine administration.
Negative_regulation (reversed) of Positive_regulation (increased) of Met-enkephalin in anterior pituitary associated with dopamine, agonist and enkephalin
16) Confidence 0.38 Published 1988 Journal Neuroendocrinology Section Abstract Doc Link 2830550 Disease Relevance 0 Pain Relevance 0.88
Alpha-2-adrenoceptor activation may lower adrenocorticotropic hormone (ACTH) by reducing secretagogue input and/or increasing the release of an inhibitory factor (CIF).
Negative_regulation (reducing) of Positive_regulation (activation) of ACTH
17) Confidence 0.37 Published 2000 Journal J. Neuroendocrinol. Section Abstract Doc Link 10971812 Disease Relevance 0 Pain Relevance 0.31
Intracerebroventricular infusion of FK-33824 inhibited the haemorrhage-induced increase in plasma concentration of ACTH. 4.
Negative_regulation (inhibited) of Positive_regulation (increase) of ACTH in plasma associated with cva and intracerebroventricular
18) Confidence 0.36 Published 1988 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 2852564 Disease Relevance 0.10 Pain Relevance 1.04
The usefulness of ACTH and CRF for treatment of pain remains to be established.
Negative_regulation (established) of Positive_regulation (usefulness) of ACTH associated with pain
19) Confidence 0.35 Published 1993 Journal Acta Neurobiol Exp (Wars) Section Abstract Doc Link 8317262 Disease Relevance 0.30 Pain Relevance 1.10
The inactivation of Met5-enkephalin was inhibited by antiserum to Ce and by specific inhibitor of CE (MK 421; I50 = 8 x 10(-9)M).
Negative_regulation (inhibited) of Positive_regulation (inactivation) of Met5-enkephalin associated with enkephalin
20) Confidence 0.34 Published 1982 Journal Adv. Biochem. Psychopharmacol. Section Abstract Doc Link 6289625 Disease Relevance 0 Pain Relevance 0.33

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