INT311844

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Context Info
Confidence 0.29
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 2.88
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Irak4) kinase activity (Irak4) cytoplasm (Irak4)
Anatomy Link Frequency
blood 2
neutrophils 1
Irak4 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 50 99.36 Very High Very High Very High
cytokine 35 90.76 High High
Arthritis 10 69.68 Quite High
Kinase C 20 65.32 Quite High
substance P 20 13.68 Low Low
Inflammation 145 5.00 Very Low Very Low Very Low
complementary and alternative medicine 50 5.00 Very Low Very Low Very Low
corticosteroid 25 5.00 Very Low Very Low Very Low
Inflammatory response 15 5.00 Very Low Very Low Very Low
headache 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
General Immunology 70 95.88 Very High Very High Very High
Pneumococcal Infection 5 95.68 Very High Very High Very High
Infection 40 94.80 High High
Neutropenia 5 94.08 High High
Lymphopenia 5 93.04 High High
Hypersensitivity 470 85.00 Quite High
Meningitis 10 79.68 Quite High
Sprains And Strains 15 78.76 Quite High
Asthma 520 76.72 Quite High
Rhinitis 140 70.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The transient nature to the manifestations of IRAK-4 deficiency has yet to be explained.
Negative_regulation (deficiency) of IRAK-4
1) Confidence 0.29 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 1.20 Pain Relevance 0.06
We evaluated a recently reported screening test for IRAK-4 deficiency based on the downregulation of CD62L (L-selectin) on blood neutrophils (PMN) upon Toll-like receptor (TLR) agonist stimulation with two known IRAK-4-deficient patients and a newborn sibling.
Negative_regulation (deficiency) of IRAK-4 in neutrophils associated with agonist
2) Confidence 0.29 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.17 Pain Relevance 0.23
Thus, CD62 analysis by flow cytometry on blood PMN following stimulation with TLR agonists is a valuable rapid screen for IRAK-4 deficiency, but LPS and PGN are not reliable stimuli to detect IRAK-4 deficiency.
Negative_regulation (deficiency) of IRAK-4 in blood associated with agonist
3) Confidence 0.29 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.18 Pain Relevance 0.19
Objective: To characterize the clinical and immunologic features of the first reported case of twins with IRAK-4 deficiency.
Negative_regulation (deficiency) of IRAK-4
4) Confidence 0.29 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 1.20 Pain Relevance 0.03
Thus, CD62 analysis by flow cytometry on blood PMN following stimulation with TLR agonists is a valuable rapid screen for IRAK-4 deficiency, but LPS and PGN are not reliable stimuli to detect IRAK-4 deficiency.
Negative_regulation (deficiency) of IRAK-4 in blood associated with agonist
5) Confidence 0.29 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.12 Pain Relevance 0.21

General Comments

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