INT311859

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Context Info
Confidence 0.19
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 2.95
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (RAB27A) protein targeting (RAB27A) Golgi apparatus (RAB27A)
GTPase activity (RAB27A) lysosome (RAB27A)
Anatomy Link Frequency
eosinophils 4
blood 1
RAB27A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 203 36.40 Quite Low
beta blocker 7 34.40 Quite Low
cytokine 49 21.52 Low Low
agonist 70 5.00 Very Low Very Low Very Low
complementary and alternative medicine 70 5.00 Very Low Very Low Very Low
corticosteroid 35 5.00 Very Low Very Low Very Low
Kinase C 28 5.00 Very Low Very Low Very Low
substance P 28 5.00 Very Low Very Low Very Low
Inflammatory response 21 5.00 Very Low Very Low Very Low
Arthritis 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rhinitis 196 98.54 Very High Very High Very High
Piebaldism 7 97.16 Very High Very High Very High
Immunodeficiency 7 96.32 Very High Very High Very High
Syndrome 21 94.56 High High
Asthma 728 80.56 Quite High
Anaphylaxis 112 54.96 Quite High
General Immunology 98 52.40 Quite High
Chronic Disease 7 39.36 Quite Low
INFLAMMATION 210 36.40 Quite Low
Eosinophilia 21 22.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conclusions: Rab27A is activated in human eosinophils following sIgA stimulation, suggesting that it may induce secretory granule movement and exocytosis in these cells.
Positive_regulation (activated) of Rab27A in eosinophils
1) Confidence 0.19 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.29 Pain Relevance 0
Results: Rab27A was expressed in human peripheral blood eosinophils and transiently activated by secretory IgA stimulation.
Positive_regulation (activated) of Rab27A in eosinophils
2) Confidence 0.14 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.47 Pain Relevance 0
In the HL-60 clone 15 cells, Rab27A was also activated by sIgA stimulation; however, the kinetics of activation were much slower than that of peripheral blood eosinophils.
Positive_regulation (activated) of Rab27A in eosinophils
3) Confidence 0.14 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.27 Pain Relevance 0
The kinetics of Rab27A activation varied between donors.
Positive_regulation (activation) of Rab27A
4) Confidence 0.13 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.45 Pain Relevance 0
Objectives: To assess Rab27A activation in human eosinophil degranulation.
Positive_regulation (activation) of Rab27A in eosinophil
5) Confidence 0.13 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.56 Pain Relevance 0
To assess Rab27A activation, we developed a novel assay allowing the pulldown of the active, GTP-bound form.
Positive_regulation (activation) of Rab27A
6) Confidence 0.13 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.48 Pain Relevance 0
High eosinophilic donors (>25 × 106cells/100 mL of blood) displayed a more rapid cycle of Rab27A activation and inactivation as compared to eosinophils from other donors (<15 × 106cells/100 mL of blood).
Positive_regulation (activation) of Rab27A in blood associated with rhinitis
7) Confidence 0.13 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.43 Pain Relevance 0

General Comments

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