INT31186

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Context Info
Confidence 0.37
First Reported 1982
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 81
Total Number 85
Disease Relevance 24.91
Pain Relevance 55.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

kinase activity (Insrr)
Anatomy Link Frequency
brain 6
spinal cord 4
platelet 3
neurons 3
cortex 2
Insrr (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 226 100.00 Very High Very High Very High
gABA 183 100.00 Very High Very High Very High
opioid receptor 130 100.00 Very High Very High Very High
antagonist 127 100.00 Very High Very High Very High
Dopamine 122 100.00 Very High Very High Very High
tolerance 91 100.00 Very High Very High Very High
Glutamate 74 100.00 Very High Very High Very High
nMDA receptor 72 100.00 Very High Very High Very High
chemokine 56 100.00 Very High Very High Very High
Analgesic 53 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 23 100.00 Very High Very High Very High
Targeted Disruption 530 99.96 Very High Very High Very High
Osteoarthritis 96 99.84 Very High Very High Very High
Sprains And Strains 37 99.80 Very High Very High Very High
Nervous System Injury 75 99.32 Very High Very High Very High
Anxiety Disorder 12 99.10 Very High Very High Very High
Urological Neuroanatomy 4 99.08 Very High Very High Very High
Hyperalgesia 120 98.84 Very High Very High Very High
Lung Injury 78 98.70 Very High Very High Very High
Apoptosis 18 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present results indicate that CXBH , CXBK and C57BL strains might be deficient in kappa ligands and/or receptor levels relevant to thermonociception .
Negative_regulation (deficient) of receptor associated with sprains and strains
1) Confidence 0.37 Published 1984 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6327334 Disease Relevance 0.78 Pain Relevance 0.26
However, the tricyclic antidepressant imipramine and the 5-HT selective reuptake inhibitor fluoxetine induced similar decreases in the time of immobility in the tail suspension test in CB(1) receptor knockout and wild-type mice.
Negative_regulation (decreases) of receptor in tail associated with targeted disruption, tricyclic antidepressant and fluoxetine
2) Confidence 0.36 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17944876 Disease Relevance 0.58 Pain Relevance 0.39
The effect of melatonin (1mg/kg, i.p.) was prevented by the pretreatment of mice with haloperidol (0.2mg/kg, i.p., a nonselective dopaminergic receptor antagonist), SCH23390 (0.05 mg/kg, s.c., a selective dopamine D1 receptor antagonist), and sulpiride (50mg/kg, i.p., a selective dopamine D2 receptor antagonist).
Negative_regulation (dopamine) of receptor associated with dopamine and antagonist
3) Confidence 0.22 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20406627 Disease Relevance 0 Pain Relevance 0.78
We have previously shown a marked reduction in the behavioural responses to formalin injection in A(2A) receptor knockout mice.
Negative_regulation (reduction) of receptor associated with targeted disruption
4) Confidence 0.19 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20570711 Disease Relevance 0.57 Pain Relevance 0.36
The authors tested whether genetically engineered mice that lack the beta3 subunit of the GABA(A) receptor differed in their sensitivities to several general anesthetic agents.
Spec (whether) Negative_regulation (lack) of ) receptor associated with gaba
5) Confidence 0.17 Published 1998 Journal Anesthesiology Section Abstract Doc Link 9523823 Disease Relevance 0 Pain Relevance 0.22
Comparison of the effects of these inhibitors on receptor binding, ligand uptake and receptor loss indicated that these cells accumulate [3H]DADLE in excess of their surface receptor number.
Negative_regulation (loss) of receptor
6) Confidence 0.12 Published 1982 Journal Life Sci. Section Abstract Doc Link 6292620 Disease Relevance 0.08 Pain Relevance 0.29
Under identical conditions the time course, dose response curve and temperature dependence for ligand uptake were similar to those for ligand-induced receptor loss (down regulation).
Negative_regulation (loss) of receptor associated with addiction
7) Confidence 0.12 Published 1982 Journal Life Sci. Section Abstract Doc Link 6292620 Disease Relevance 0.09 Pain Relevance 0.31
Conversely, blockade of the dopaminergic system in D2 receptor knock-out mice triggers an increase in enkephalin supporting the important physiological relationship between both systems.
Negative_regulation (blockade) of receptor associated with targeted disruption and enkephalin
8) Confidence 0.12 Published 2005 Journal Neuroscience Section Abstract Doc Link 16084652 Disease Relevance 0.10 Pain Relevance 0.51
Both toluene and TCE decreased benzodiazepine receptor binding levels in discrete brain areas, but had no effect on NMDA receptor levels.
Negative_regulation (decreased) of receptor in brain associated with nmda receptor
9) Confidence 0.11 Published 2008 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 18991886 Disease Relevance 0.27 Pain Relevance 1.26
Inhibition of diazepam on morphine-induced hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity.
Negative_regulation (Inhibition) of receptor associated with dopamine receptor, tolerance, attention deficit hyperactivity disorder and morphine
10) Confidence 0.10 Published 2001 Journal Pharmacol. Res. Section Title Doc Link 11735352 Disease Relevance 0.50 Pain Relevance 1.26
Mice lacking opioid receptor and opioid peptide precursor genes have now been produced by gene targeting.
Negative_regulation (lacking) of receptor associated with opioid receptor and opioid
11) Confidence 0.07 Published 2002 Journal Neuropeptides Section Abstract Doc Link 12359497 Disease Relevance 0.27 Pain Relevance 0.68
Gene disruption of the kinin B(2) receptor did not interfere with CFA-induced hyperalgesia, but ablation of the gene of the B(1) receptor reduced the hyperalgesia in both ipsilateral (48+/-13%, at 12 h) and contralateral (91+/-22%, at 12 h) paws.
Negative_regulation (disruption) of receptor associated with hyperalgesia
12) Confidence 0.06 Published 2001 Journal Neuropharmacology Section Abstract Doc Link 11747905 Disease Relevance 0.82 Pain Relevance 0.43
Treatment of wild-type mice with the selective B(1) antagonist des-Arg(9)-[Leu(8)]-BK (150 nmol/kg, s.c.) reduced CFA-evoked thermal hyperalgesia, to an extent which was similar to that observed in mice lacking kinin B(1) receptor.
Negative_regulation (lacking) of receptor associated with thermal hyperalgesia and antagonist
13) Confidence 0.06 Published 2001 Journal Neuropharmacology Section Abstract Doc Link 11747905 Disease Relevance 1.01 Pain Relevance 0.52
After repeated morphine injection, B6 mice exhibited a decrease in striatal [3H]DAMGO binding, indicating a downregulation of receptor density by approximately 45% (p=.0003 vs saline-treated B6), a phenomenon not observed in D2 mice.
Negative_regulation (downregulation) of receptor associated with morphine
14) Confidence 0.06 Published 1997 Journal Life Sci. Section Abstract Doc Link 9366513 Disease Relevance 0.48 Pain Relevance 0.57
Disruption of the type 1 inositol 1,4,5-trisphosphate receptor gene suppresses the morphine-induced antinociception in the mouse.
Negative_regulation (Disruption) of receptor associated with antinociception, analgesic and morphine
15) Confidence 0.05 Published 2003 Journal Neurosci. Lett. Section Title Doc Link 12972155 Disease Relevance 0 Pain Relevance 0.95
Etorphine treatment decreased ( approximately 25-40%) mu-receptor density similarly in both strains throughout treatment.
Negative_regulation (decreased) of receptor associated with sprains and strains and immobilon
16) Confidence 0.05 Published 2000 Journal Synapse Section Abstract Doc Link 10881033 Disease Relevance 0.44 Pain Relevance 1.35
The behavioural stimulation evoked in rats by non-competitive (MK-801, (+)-5-methyl-10,11-dihydroxy-5H-dibenzo (a,b)-cyclohepten-5,10-imine hydrogen maleate) or competitive (CGP 37849, D,L-E-amino-4-methyl-5-phosphono-3-pentenoic acid) NMDA receptor antagonists was also inhibited.
Negative_regulation (inhibited) of receptor associated with nmda receptor antagonist
17) Confidence 0.04 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8982660 Disease Relevance 0.58 Pain Relevance 0.48
In situ hybridization showed no changes in 5-HT(2A) receptor and serotonin transporter mRNA levels, whereas 5-HT(2C) receptor mRNA levels were reduced in certain brain regions.
Negative_regulation (reduced) of receptor in brain associated with serotonin
18) Confidence 0.04 Published 2002 Journal J. Neurosci. Res. Section Abstract Doc Link 11754082 Disease Relevance 0.15 Pain Relevance 0.31
The enhancement of morphine antinociception seen in the presence of blockade of the CCKB receptor may be the result of the well-known enhancement of morphine antinociception by opioid delta agonists.
Negative_regulation (blockade) of CCKB receptor associated with antinociception, agonist, opioid and morphine
19) Confidence 0.04 Published 1994 Journal Neuroreport Section Abstract Doc Link 7696612 Disease Relevance 0 Pain Relevance 2.14
Naloxonazine, irreversible antagonist of the pharmacologically defined mu 1 opioid receptor, and beta-funaltrexamine (beta-FNA), that also displays irreversible antagonism at mu 1/2 receptors, when injected i.c.v. 24 h before the opioids significantly reduced the activity of DAMGO and morphine.
Negative_regulation (irreversible) of receptor associated with antagonist, opioid receptor, opioid and morphine
20) Confidence 0.04 Published 1995 Journal Life Sci. Section Abstract Doc Link 7475889 Disease Relevance 0 Pain Relevance 1.15

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