INT311872

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.35
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp9) extracellular space (Mmp9) extracellular region (Mmp9)
proteinaceous extracellular matrix (Mmp9) extracellular matrix organization (Mmp9) protein complex (Mmp9)
Anatomy Link Frequency
mast cell 2
IGHE (Homo sapiens)
Mmp9 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 58 96.32 Very High Very High Very High
cytokine 14 80.92 Quite High
agonist 20 5.00 Very Low Very Low Very Low
complementary and alternative medicine 20 5.00 Very Low Very Low Very Low
corticosteroid 10 5.00 Very Low Very Low Very Low
Kinase C 8 5.00 Very Low Very Low Very Low
substance P 8 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 24 99.44 Very High Very High Very High
Hypersensitivity 188 99.08 Very High Very High Very High
Asthma 208 98.36 Very High Very High Very High
INFLAMMATION 60 96.32 Very High Very High Very High
Airway Remodeling 2 95.64 Very High Very High Very High
Rhinitis 56 50.92 Quite High
Stress 44 5.00 Very Low Very Low Very Low
Urticaria 32 5.00 Very Low Very Low Very Low
Anaphylaxis 32 5.00 Very Low Very Low Very Low
General Immunology 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hypothesis: IgE-induced mast cell activation in vivo induces the release of mediators involved in tissue remodeling, such as MMP-9, in the absence of specific antigen.
IgE Positive_regulation (induces) of Localization (release) of MMP-9 in mast cell
1) Confidence 0.01 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.78 Pain Relevance 0.14
Methods: To study whether IgE could upregulate MMP-9 release in vivo in the absence of allergen, we injected monomeric IgE (25 ?
IgE Positive_regulation (upregulate) of Localization (release) of MMP-9
2) Confidence 0.01 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.57 Pain Relevance 0.08

General Comments

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