INT311881

Context Info Confidence 0.22 First Reported 2010 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.97 Pain Relevance 0.29

cell differentiation (Tgfbr1) signal transduction (Tgfbr1) cell motility (Tgfbr1) plasma membrane (Tgfbr1) embryo development (Tgfbr1) protein complex (Tgfbr1)

Anatomy Link Frequency medial 1 lateral 1 Tgfbr1 (Mus musculus)

Pain Link Frequency Relevance Heat Osteoarthritis 91 98.16 cytokine 5 5.00 metalloproteinase 3 5.00 fibrosis 2 5.00 Inflammation 1 5.00 Arthritis 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Osteoarthritis 96 98.16 Aging 13 92.52 Disease 12 81.92 Apoptosis 1 18.84 Hypertrophy 5 5.00 Fibrosis 2 5.00 Arthropathy 2 5.00 Osteophyte 1 5.00 Arthritis 1 5.00 Necrosis 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A more than threefold increase in the ALK1/ALK5 ratio was observed on the medial side while the ratio on the lateral side was unaffected.

Neg (unaffected) Regulation (unaffected) of in lateral Positive_regulation (increase) of ALK5 in medial

1) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.97 Pain Relevance 0.29

General Comments

This test has worked.