INT311882

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.25
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.99
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

homeostatic process (Smad1) nucleus (Smad1) intracellular (Smad1)
cytoplasm (Smad1)
Anatomy Link Frequency
chondrocytes 1
Smad1 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 182 98.60 Very High Very High Very High
fibrosis 4 92.28 High High
metalloproteinase 6 40.64 Quite Low
cytokine 10 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 192 98.60 Very High Very High Very High
Fibrosis 4 92.28 High High
Disease 24 80.08 Quite High
Disease Progression 2 72.32 Quite High
Frailty 2 69.36 Quite High
Arthropathy 4 45.60 Quite Low
Cancer 2 33.76 Quite Low
Necrosis 2 33.28 Quite Low
Aging 26 5.00 Very Low Very Low Very Low
Hypertrophy 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of general inhibition of the Smad1/5/8 pathway in elderly people are hard to predict but this might interfere with bone metabolism.
Negative_regulation (inhibition) of Smad1
1) Confidence 0.25 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.55 Pain Relevance 0.20
An alternative strategy would be blocking ALK1 or the Smad1/5/8 pathway in chondrocytes to block the trigger that stimulates progression of chondrocyte differentiation.
Negative_regulation (blocking) of Smad1 in chondrocytes
2) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.45 Pain Relevance 0.18

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox