INT311884

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Context Info
Confidence 0.30
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 2.16
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Acvrl1) kinase activity (Acvrl1)
Anatomy Link Frequency
chondrocyte 2
Acvrl1 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 10 99.92 Very High Very High Very High
Osteoarthritis 455 98.60 Very High Very High Very High
metalloproteinase 15 24.56 Low Low
cytokine 25 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 10 99.92 Very High Very High Very High
Osteoarthritis 480 98.60 Very High Very High Very High
Disease 60 80.08 Quite High
Aging 65 63.84 Quite High
Disease Progression 5 56.24 Quite High
Frailty 5 53.28 Quite High
Alzheimer's Dementia 5 40.24 Quite Low
Arthropathy 10 29.52 Quite Low
Cancer 5 17.68 Low Low
Necrosis 5 17.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since ALK1 is involved in vessel formation, blocking ALK1 can interfere with this process [99].
Negative_regulation (blocking) of ALK1
1) Confidence 0.30 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.42 Pain Relevance 0.18
Blocking ALK1 will have few side effects due to the restricted effect of ALK1 in vessel formation, which is anticipated to be relatively unimportant in elderly people.
Negative_regulation (Blocking) of ALK1
2) Confidence 0.30 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.40 Pain Relevance 0.15
General blocking of the Smad1/5/8 pathway using kinase blockers that inhibit the activity of ALK1, ALK2, ALK3 and ALK6 is an alternative option to stop chondrocyte aberrant differentiation.
Negative_regulation (inhibit) of ALK1 in chondrocyte
3) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.30 Pain Relevance 0.12
An alternative strategy would be blocking ALK1 or the Smad1/5/8 pathway in chondrocytes to block the trigger that stimulates progression of chondrocyte differentiation.
Negative_regulation (blocking) of ALK1 in chondrocytes
4) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.45 Pain Relevance 0.18
In old animals, showing a decrease in the ALK5/ALK1 ratio, the protective effect of TGF?
Negative_regulation (decrease) of ALK1
5) Confidence 0.10 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.58 Pain Relevance 0.19

General Comments

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