INT311885

Context Info Confidence 0.44 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.35 Pain Relevance 0.06

cell differentiation (Tgfbr1) signal transduction (Tgfbr1) cell motility (Tgfbr1) plasma membrane (Tgfbr1) embryo development (Tgfbr1) protein complex (Tgfbr1)

Tgfbr1 (Mus musculus)

Pain Link Frequency Relevance Heat Osteoarthritis 91 71.04 cytokine 5 5.00 metalloproteinase 4 5.00 fibrosis 3 5.00 palliative 1 5.00 Inflammation 1 5.00 Pain 1 5.00 Immobilon 1 5.00 Arthritis 1 5.00

Disease Link Frequency Relevance Heat Cancer 38 86.16 Osteoarthritis 96 71.04 Aging 37 70.76 Disease 13 34.56 Apoptosis 19 5.00 Injury 8 5.00 Adhesions 7 5.00 Hypertrophy 5 5.00 Fibrosis 3 5.00 Metastasis 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Radiation also induced expression of PAI-1 mRNA, an ALK5 target gene, which was inhibited by the small molecular ALK5 inhibitor SB431542 (Figure 8b).

Positive_regulation (induced) of Gene_expression (expression) of ALK5

1) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884035 Disease Relevance 0.09 Pain Relevance 0

In addition, overexpression of constitutive active ALK5 (Smad2/3) results in increased expression of aggrecan while constitutive ALK1 (Smad1/5/8) expression leads to elevated expression of MMP-13.

Positive_regulation (overexpression) of Gene_expression (overexpression) of ALK5

2) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.26 Pain Relevance 0.06

General Comments

This test has worked.