INT311890

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Context Info
Confidence 0.23
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.46
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

homeostatic process (Smad1) nucleus (Smad1) intracellular (Smad1)
cytoplasm (Smad1)
Anatomy Link Frequency
chondrocyte 1
Smad1 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 91 83.52 Quite High
cytokine 5 5.00 Very Low Very Low Very Low
fibrosis 5 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Buprenorphine 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 5 90.76 High High
Osteoarthritis 96 83.52 Quite High
Disease 12 83.08 Quite High
Aging 13 71.40 Quite High
Targeted Disruption 1 53.76 Quite High
Death 1 22.28 Low Low
Osteoporosis 11 5.00 Very Low Very Low Very Low
Fibrosis 7 5.00 Very Low Very Low Very Low
Repression 2 5.00 Very Low Very Low Very Low
Marfan Syndrome 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They showed that SB431542 enhanced the effects of BMP-2 on osteogenesis and that this was associated with increased SMAD1 signaling and decreased SMAD2 signaling.
SMAD1 Binding (associated) of
1) Confidence 0.23 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2896919 Disease Relevance 0 Pain Relevance 0
Signaling via Smad1 cooperates with the transcription factor Runx2 (CBFA1) to induce chondrocyte terminal differentiation.
Smad1 Binding (Signaling) of in chondrocyte
2) Confidence 0.16 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.46 Pain Relevance 0.04

General Comments

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