INT311891

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Context Info
Confidence 0.51
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.34
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

homeostatic process (Smad1) nucleus (Smad1) intracellular (Smad1)
cytoplasm (Smad1)
Anatomy Link Frequency
chondrocyte 1
endothelial cells 1
Smad1 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 273 73.80 Quite High
fibrosis 12 44.72 Quite Low
metalloproteinase 9 26.04 Quite Low
cytokine 15 17.72 Low Low
Inflammation 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Buprenorphine 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 3 99.08 Very High Very High Very High
Hypertrophy 15 96.80 Very High Very High Very High
Osteoarthritis 288 73.80 Quite High
Aging 39 73.52 Quite High
Osteoporosis 22 72.96 Quite High
Disease 36 61.12 Quite High
Fibrosis 16 44.72 Quite Low
Arthropathy 6 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 5 5.00 Very Low Very Low Very Low
Repression 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The phosphorylation status of SMAD1 and SMAD2 were assayed as representative of the activity of the osteogenic (BMP-stimulated) and non-osteogenic (TGF-?
Phosphorylation (phosphorylation) of SMAD1
1) Confidence 0.51 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2896919 Disease Relevance 0.20 Pain Relevance 0
The phosphorylated (pSMAD1, pSMAD2) forms of the protein were examined by western blotting, with total SMAD1 and ?
Spec (examined) Phosphorylation (phosphorylated) of pSMAD1
2) Confidence 0.44 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2896919 Disease Relevance 0.17 Pain Relevance 0
Moreover, in vivo inhibition of Smad1/5/8 phosphorylation, as observed in Smad6 transgenic mice, was associated with delayed chondrocyte hypertrophy [68].
Phosphorylation (phosphorylation) of Smad1 in chondrocyte associated with targeted disruption and hypertrophy
3) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.48 Pain Relevance 0.03
results in both Smad2/3 and Smad1/5/8 phosphorylation within 15 to 30 minutes [85].
Phosphorylation (phosphorylation) of Smad1
4) Confidence 0.26 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.31 Pain Relevance 0.09
In endothelial cells, but also in chondrocytes, activation of the ALK5 route is followed by Smad2 or Smad3 phosphorylation while ALK1 has been found to result in phosphorylation of Smad1, Smad5, or Smad8 [29-31].
Phosphorylation (phosphorylation) of Smad1 in endothelial cells
5) Confidence 0.26 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.18 Pain Relevance 0.06

General Comments

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