INT311896

Context Info Confidence 0.08 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.30 Pain Relevance 0.12

embryo development (Acvr1) kinase activity (Acvr1)

Anatomy Link Frequency chondrocyte 1 Acvr1 (Mus musculus)

Pain Link Frequency Relevance Heat Osteoarthritis 91 92.36 fibrosis 2 67.92 cytokine 5 5.00 metalloproteinase 3 5.00 Inflammation 1 5.00 Arthritis 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Osteoarthritis 96 92.36 Fibrosis 2 67.92 Disease 12 61.92 Disease Progression 1 22.32 Frailty 1 19.36 Aging 13 5.00 Hypertrophy 5 5.00 Arthropathy 2 5.00 Osteophyte 1 5.00 Arthritis 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

General blocking of the Smad1/5/8 pathway using kinase blockers that inhibit the activity of ALK1, ALK2, ALK3 and ALK6 is an alternative option to stop chondrocyte aberrant differentiation.

Negative_regulation (inhibit) of ALK2 in chondrocyte

1) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.30 Pain Relevance 0.12

General Comments

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