INT311898

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Context Info
Confidence 0.33
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.53
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Smad6) intracellular (Smad6)
Anatomy Link Frequency
chondrocytes 2
Smad6 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 91 70.00 Quite High
cytokine 5 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 5 96.84 Very High Very High Very High
Targeted Disruption 1 81.12 Quite High
Osteoarthritis 96 70.00 Quite High
Disease 12 69.56 Quite High
Aging 13 57.88 Quite High
Fibrosis 2 5.00 Very Low Very Low Very Low
Arthropathy 2 5.00 Very Low Very Low Very Low
Osteophyte 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Blocking the Smad1/5/8 route by overexpression of Smad6 reduced the expression of both type X collagen and alkaline phosphatase activity in chondrocytes, while using Smad6 antisense had an opposite effect [67].
Positive_regulation (overexpression) of Gene_expression (overexpression) of Smad6 in chondrocytes
1) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.53 Pain Relevance 0.04

General Comments

This test has worked.

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