INT311902

Context Info Confidence 0.13 First Reported 2010 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.87 Pain Relevance 0.26

signal transduction (Acvrl1, Tgfbr1) kinase activity (Acvrl1, Tgfbr1) cell differentiation (Tgfbr1) cell motility (Tgfbr1) plasma membrane (Tgfbr1) embryo development (Tgfbr1)

Acvrl1 (Mus musculus) Tgfbr1 (Mus musculus)

Pain Link Frequency Relevance Heat Osteoarthritis 91 95.08 cytokine 5 5.00 metalloproteinase 3 5.00 fibrosis 2 5.00 Inflammation 1 5.00 Arthritis 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Disease 12 96.28 Osteoarthritis 96 95.08 Aging 13 90.72 Apoptosis 1 33.20 Hypertrophy 5 5.00 Fibrosis 2 5.00 Arthropathy 2 5.00 Osteophyte 1 5.00 Arthritis 1 5.00 Necrosis 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

receptor, ALK1, did not decrease to a similar extent as ALK5 [85].

ALK1 Neg (not) Negative_regulation (decrease) of ALK5

1) Confidence 0.13 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.87 Pain Relevance 0.26

General Comments

This test has worked.