INT311903

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.27
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Mmp13) signal transduction (Acvrl1) extracellular space (Mmp13)
peptidase activity (Mmp13) extracellular region (Mmp13) proteinaceous extracellular matrix (Mmp13)
Anatomy Link Frequency
chondrocytes 2
Acvrl1 (Mus musculus)
Mmp13 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 91 64.24 Quite High
cytokine 5 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 96 87.36 High High
Aging 13 59.84 Quite High
Disease 12 23.64 Low Low
Hypertrophy 5 5.00 Very Low Very Low Very Low
Fibrosis 2 5.00 Very Low Very Low Very Low
Arthropathy 2 5.00 Very Low Very Low Very Low
Osteophyte 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ALK1 (Smad1/5/8) and ALK5 (Smad3) signaling balance in chondrocytes apparently determines MMP-13 expression.
ALK1 Spec (determines) Negative_regulation (determines) of Spec (determines) Gene_expression (expression) of MMP-13 in chondrocytes
1) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.27 Pain Relevance 0.06

General Comments

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