INT311904

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Context Info
Confidence 0.13
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.44
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Smad2, Smad1) intracellular (Smad2, Smad1) cytoplasm (Smad2, Smad1)
homeostatic process (Smad1) protein complex (Smad2) transcription factor binding (Smad2)
Anatomy Link Frequency
articular 2
Smad2 (Mus musculus)
Smad1 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 91 54.24 Quite High
cytokine 5 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 5 97.32 Very High Very High Very High
Targeted Disruption 1 95.00 High High
Osteoarthritis 96 54.24 Quite High
Disease 12 53.80 Quite High
Aging 13 42.12 Quite Low
Fibrosis 2 5.00 Very Low Very Low Very Low
Arthropathy 2 5.00 Very Low Very Low Very Low
Osteophyte 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In articular chondrocytes treated with azacytidine, reduced Smad2 and Smad3 expression and signaling and increased Smad1/5 expression correlated with elevated synthesis of type X collagen and alkaline phosphatase.
Smad2 Positive_regulation (increased) of Gene_expression (expression) of Smad1 in articular
1) Confidence 0.13 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.44 Pain Relevance 0.03

General Comments

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