INT311910

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Context Info
Confidence 0.12
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.24
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Acvrl1) homeostatic process (Smad1) nucleus (Smad1)
intracellular (Smad1) kinase activity (Acvrl1) cytoplasm (Smad1)
Anatomy Link Frequency
endothelial cells 2
Acvrl1 (Mus musculus)
Smad1 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 91 65.56 Quite High
metalloproteinase 3 27.36 Quite Low
cytokine 5 19.04 Low Low
fibrosis 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 96 65.56 Quite High
Aging 13 65.28 Quite High
Disease 12 7.60 Low Low
Hypertrophy 5 5.00 Very Low Very Low Very Low
Fibrosis 2 5.00 Very Low Very Low Very Low
Arthropathy 2 5.00 Very Low Very Low Very Low
Osteophyte 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In endothelial cells, but also in chondrocytes, activation of the ALK5 route is followed by Smad2 or Smad3 phosphorylation while ALK1 has been found to result in phosphorylation of Smad1, Smad5, or Smad8 [29-31].
ALK1 Positive_regulation (result) of Phosphorylation (phosphorylation) of Smad1 in endothelial cells
1) Confidence 0.12 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.24 Pain Relevance 0.06

General Comments

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