INT311911

Context Info Confidence 0.10 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.55 Pain Relevance 0.23

cell differentiation (Tgfbr1) Golgi apparatus (Mmp13) embryo development (Tgfbr1) protein complex (Tgfbr1) peptidase activity (Mmp13) extracellular space (Mmp13)

Anatomy Link Frequency chondrocytes 2 Tgfbr1 (Mus musculus) Mmp13 (Mus musculus)

Pain Link Frequency Relevance Heat Osteoarthritis 91 94.72 cytokine 5 5.00 metalloproteinase 3 5.00 fibrosis 2 5.00 Inflammation 1 5.00 Arthritis 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Aging 13 97.28 Osteoarthritis 96 94.72 Disease 12 5.00 Hypertrophy 5 5.00 Fibrosis 2 5.00 Arthropathy 2 5.00 Osteophyte 1 5.00 Arthritis 1 5.00 Necrosis 1 5.00 Alzheimer's Dementia 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Importantly, signaling via ALK1, but not ALK5, stimulates MMP-13 expression by chondrocytes.

ALK5 Positive_regulation (stimulates) of Gene_expression (expression) of MMP-13 in chondrocytes

1) Confidence 0.10 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2875624 Disease Relevance 0.55 Pain Relevance 0.23

General Comments

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