INT311912

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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.51
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Mmp13) intracellular (Smad1) cytoplasm (Smad1)
peptidase activity (Mmp13) extracellular space (Mmp13) extracellular region (Mmp13)
Smad1 (Mus musculus)
Mmp13 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 182 66.16 Quite High
cytokine 10 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 192 71.52 Quite High
Aging 26 65.88 Quite High
Disease 24 29.68 Quite Low
Hypertrophy 10 5.00 Very Low Very Low Very Low
Fibrosis 4 5.00 Very Low Very Low Very Low
Arthropathy 4 5.00 Very Low Very Low Very Low
Osteophyte 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, overexpression of constitutive active ALK5 (Smad2/3) results in increased expression of aggrecan while constitutive ALK1 (Smad1/5/8) expression leads to elevated expression of MMP-13.
Gene_expression (expression) of Smad1 Positive_regulation (elevated) of Gene_expression (expression) of MMP-13
1) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.26 Pain Relevance 0.06
In addition, overexpression of constitutive active ALK5 (Smad2/3) results in increased expression of aggrecan while constitutive ALK1 (Smad1/5/8) expression leads to elevated expression of MMP-13.
Gene_expression (expression) of Smad1 Positive_regulation (leads) of Gene_expression (expression) of MMP-13
2) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.26 Pain Relevance 0.06

General Comments

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