INT311914

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.94
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Col2a1) extracellular region (Col2a1) proteinaceous extracellular matrix (Col2a1)
cytoplasm (Col2a1)
Anatomy Link Frequency
chondrocytes 4
Il1 (Mus musculus)
Col2a1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 6 100.00 Very High Very High Very High
Osteoarthritis 182 99.28 Very High Very High Very High
cytokine 10 95.16 Very High Very High Very High
Arthritis 2 27.32 Quite Low
Inflammation 2 26.92 Quite Low
fibrosis 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 192 99.28 Very High Very High Very High
Aging 26 45.04 Quite Low
Arthritis 2 27.32 Quite Low
Hypertrophy 10 13.28 Low Low
Disease 24 5.00 Very Low Very Low Very Low
Fibrosis 4 5.00 Very Low Very Low Very Low
Arthropathy 4 5.00 Very Low Very Low Very Low
Osteophyte 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-1 can stimulate chondrocytes to produce nitric oxide [17], matrix metalloproteinases [18] and aggrecanases (ADAMTS) [19], and suppresses the synthesis of aggrecan and collagen type II [20-22].
IL-1 Negative_regulation (suppresses) of Gene_expression (synthesis) of collagen type II in chondrocytes associated with metalloproteinase
1) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.98 Pain Relevance 0.67
IL-1 is a potent inhibitor of chondrocyte type II collagen synthesis, but type II collagen synthesis is increased during OA as discussed above.
IL-1 Negative_regulation (inhibitor) of Gene_expression (synthesis) of type II collagen in chondrocyte associated with osteoarthritis
2) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.96 Pain Relevance 0.56

General Comments

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