INT311916

Context Info Confidence 0.12 First Reported 2010 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.27 Pain Relevance 0.06

transport (Smad3) Golgi apparatus (Mmp13) intracellular (Smad3) DNA binding (Smad3) protein complex (Smad3) cytoplasm (Smad3)

Anatomy Link Frequency chondrocytes 2 Smad3 (Mus musculus) Mmp13 (Mus musculus)

Pain Link Frequency Relevance Heat Osteoarthritis 91 64.24 cytokine 5 5.00 metalloproteinase 3 5.00 fibrosis 2 5.00 Inflammation 1 5.00 Arthritis 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Osteoarthritis 96 87.36 Aging 13 58.76 Disease 12 22.56 Hypertrophy 5 5.00 Fibrosis 2 5.00 Arthropathy 2 5.00 Osteophyte 1 5.00 Arthritis 1 5.00 Necrosis 1 5.00 Alzheimer's Dementia 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The ALK1 (Smad1/5/8) and ALK5 (Smad3) signaling balance in chondrocytes apparently determines MMP-13 expression.

Smad3 Spec (determines) Negative_regulation (determines) of Spec (determines) Gene_expression (expression) of MMP-13 in chondrocytes

1) Confidence 0.12 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.27 Pain Relevance 0.06

General Comments

This test has worked.