INT311917

Context Info Confidence 0.10 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.31 Pain Relevance 0.08

cell differentiation (Tgfbr1) Golgi apparatus (Mmp13) embryo development (Tgfbr1) protein complex (Tgfbr1) peptidase activity (Mmp13) extracellular space (Mmp13)

Tgfbr1 (Mus musculus) Mmp13 (Mus musculus)

Pain Link Frequency Relevance Heat Osteoarthritis 91 63.32 cytokine 5 5.00 metalloproteinase 3 5.00 fibrosis 2 5.00 Inflammation 1 5.00 Arthritis 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Osteoarthritis 96 77.92 Aging 13 63.04 Disease 12 26.84 Hypertrophy 5 5.00 Fibrosis 2 5.00 Arthropathy 2 5.00 Osteophyte 1 5.00 Arthritis 1 5.00 Necrosis 1 5.00 Alzheimer's Dementia 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Blocking ALK5 expression using siRNA resulted in elevated expression of MMP-13 [85].

Gene_expression (expression) of ALK5 Positive_regulation (resulted) of Gene_expression (expression) of MMP-13

1) Confidence 0.10 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.31 Pain Relevance 0.08

General Comments

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