INT311926

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Context Info
Confidence 0.26
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.48
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NRP1, SEMA3A) extracellular region (NRP1, SEMA3A) cytosol (NRP1)
signal transduction (NRP1) cell adhesion (NRP1) plasma membrane (NRP1)
NRP1 (Homo sapiens)
SEMA3A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 9 79.00 Quite High
dorsal root ganglion 3 44.04 Quite Low
Chronic low back pain 27 5.00 Very Low Very Low Very Low
Nerve growth factor 18 5.00 Very Low Very Low Very Low
Pain 18 5.00 Very Low Very Low Very Low
backache 12 5.00 Very Low Very Low Very Low
imagery 9 5.00 Very Low Very Low Very Low
Sciatica 3 5.00 Very Low Very Low Very Low
calcitonin gene related peptide 3 5.00 Very Low Very Low Very Low
substance P 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 3 87.84 High High
Hyperplasia 3 78.48 Quite High
Shock 6 60.32 Quite High
Hypoxia 9 53.32 Quite High
Ganglion Cysts 3 44.04 Quite Low
Low Back Pain 39 5.00 Very Low Very Low Very Low
Nociception 15 5.00 Very Low Very Low Very Low
Pain 9 5.00 Very Low Very Low Very Low
Intervertebral Disk Degeneration 9 5.00 Very Low Very Low Very Low
Nerve Root Compression 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The neuropilins consist of two members; NRP1 which is thought to be the principal receptor for sema3A and NRP2 which is thought to be the principal receptor for sema3F [36-39].
NRP1 Binding (receptor) of sema3A
1) Confidence 0.26 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875625 Disease Relevance 0.06 Pain Relevance 0.04
This suggests that sem3A may be secreted by a healthy disc cell and then bind to a NRP-1 molecule on the same cell or a neighbouring cell.
NRP-1 molecule Binding (bind) of sem3A
2) Confidence 0.25 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875625 Disease Relevance 0.16 Pain Relevance 0
For example, sema3A has a high affinity for NRP-1 and NRP-1 was expressed highly by the disc cells as well as PLXA3.
NRP-1 Binding (affinity) of sema3A
3) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875625 Disease Relevance 0.26 Pain Relevance 0

General Comments

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