INT311940

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Context Info
Confidence 0.56
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.71
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (SEMA3A) extracellular region (SEMA3A)
SEMA3A (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 18 63.28 Quite High
cytokine 9 47.36 Quite Low
dorsal root ganglion 3 12.40 Low Low
Chronic low back pain 27 5.00 Very Low Very Low Very Low
Nerve growth factor 18 5.00 Very Low Very Low Very Low
backache 12 5.00 Very Low Very Low Very Low
imagery 9 5.00 Very Low Very Low Very Low
Sciatica 3 5.00 Very Low Very Low Very Low
calcitonin gene related peptide 3 5.00 Very Low Very Low Very Low
substance P 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 9 98.54 Very High Very High Very High
Shock 6 90.96 High High
Hyperplasia 3 58.88 Quite High
Intervertebral Disk Degeneration 9 55.84 Quite High
Ganglion Cysts 3 12.40 Low Low
Low Back Pain 39 5.00 Very Low Very Low Very Low
Nociception 15 5.00 Very Low Very Low Very Low
Pain 9 5.00 Very Low Very Low Very Low
Nerve Root Compression 3 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, as well as binding members of the PLX family the NRPs bind VEGF receptors to enhance VEGF165 activity suggesting they also play a role in regulating angiogenesis through the competitive inhibition of sema3A and VEGF against one another for overlapping binding sites on the NRP molecule [45,46].
Negative_regulation (inhibition) of sema3A
1) Confidence 0.56 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875625 Disease Relevance 0.15 Pain Relevance 0
These hypoxic conditions may be a driving force for VEGF upregulation which may cause inhibition of sema3A activity through competitive receptor binding.
Negative_regulation (inhibition) of sema3A associated with hypoxia
2) Confidence 0.56 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875625 Disease Relevance 0.35 Pain Relevance 0
This reduction in sema3A essentially withdraws the competition against VEGF and may therefore allow angiogenesis to occur as a result of VEGF binding.
Negative_regulation (reduction) of sema3A
3) Confidence 0.49 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875625 Disease Relevance 0.22 Pain Relevance 0.06

General Comments

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