INT311943

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Context Info
Confidence 0.56
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0.66
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (SEMA3A) extracellular region (SEMA3A)
Anatomy Link Frequency
neural 2
nucleus pulposus 2
SEMA3A (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 36 95.20 Very High Very High Very High
backache 24 89.08 High High
Chronic low back pain 54 48.68 Quite Low
Nerve growth factor 36 5.00 Very Low Very Low Very Low
cytokine 18 5.00 Very Low Very Low Very Low
imagery 18 5.00 Very Low Very Low Very Low
dorsal root ganglion 6 5.00 Very Low Very Low Very Low
Sciatica 6 5.00 Very Low Very Low Very Low
calcitonin gene related peptide 6 5.00 Very Low Very Low Very Low
substance P 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Low Back Pain 78 89.08 High High
Nociception 30 83.52 Quite High
Pain 18 81.68 Quite High
Hypoxia 18 78.88 Quite High
Hyperplasia 6 17.92 Low Low
Intervertebral Disk Degeneration 18 5.00 Very Low Very Low Very Low
Shock 12 5.00 Very Low Very Low Very Low
Nerve Root Compression 6 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Necrosis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Areas of the degenerate OAF were particularly deprived of sema3A expression in comparison to the healthy disc, demonstrating a significant difference between PM normal and surgical degenerate or painful samples.
Negative_regulation (deprived) of Gene_expression (expression) of sema3A associated with pain
1) Confidence 0.56 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875625 Disease Relevance 0 Pain Relevance 0.10
Again, this supports our hypothesis that as expression of sema3A is reduced with degeneration, there is a disinhibition of neural and vascular ingrowth.
Negative_regulation (reduced) of Gene_expression (expression) of sema3A in neural
2) Confidence 0.56 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875625 Disease Relevance 0 Pain Relevance 0.09
We have shown that as the disc degenerates sema3A expression is reduced.
Negative_regulation (reduced) of Gene_expression (expression) of sema3A
3) Confidence 0.49 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875625 Disease Relevance 0.21 Pain Relevance 0.06
Our study is the first to localise expression of sema3A (an axonal inhibitory molecule) in the IVD and as such we have established a distinct regional variation in expression throughout the disc.
Negative_regulation (localise) of Gene_expression (expression) of sema3A
4) Confidence 0.41 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875625 Disease Relevance 0.33 Pain Relevance 0.25
In degenerate samples, sema3A expression decreased significantly in this region, although cell clusters within the degenerate nucleus pulposus exhibited strong immunopositivity. mRNA for sema3A receptors was also identified in healthy and degenerate tissues.
Negative_regulation (decreased) of Gene_expression (expression) of sema3A in nucleus pulposus
5) Confidence 0.36 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2875625 Disease Relevance 0.11 Pain Relevance 0.06
This reduction in sema3A expression was significant (P ?
Negative_regulation (reduction) of Gene_expression (expression) of sema3A
6) Confidence 0.36 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875625 Disease Relevance 0 Pain Relevance 0

General Comments

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