INT311944

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Context Info
Confidence 0.39
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.17
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NRP2) cell adhesion (NRP2) plasma membrane (NRP2)
Anatomy Link Frequency
neural 2
NRP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic low back pain 9 27.84 Quite Low
cytokine 3 23.60 Low Low
imagery 3 21.68 Low Low
Sciatica 1 9.52 Low Low
Nerve growth factor 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
backache 4 5.00 Very Low Very Low Very Low
dorsal root ganglion 1 5.00 Very Low Very Low Very Low
calcitonin gene related peptide 1 5.00 Very Low Very Low Very Low
substance P 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Intervertebral Disk Degeneration 3 99.90 Very High Very High Very High
Shock 2 67.20 Quite High
Death 1 36.88 Quite Low
Low Back Pain 13 27.84 Quite Low
Nerve Root Compression 1 9.52 Low Low
Nociception 5 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Hypoxia 3 5.00 Very Low Very Low Very Low
Hyperplasia 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As IVD cells are phenotypically similar to chondrocytes [48] we hypothesised that cells of the healthy IVD may express semaphorins as a means of repelling neurovascular invasion, and in disc degeneration the expression of semaphorins may be reduced causing a disinhibition of neural and vascular ingrowth.
Negative_regulation (reduced) of Gene_expression (expression) of semaphorins in neural associated with intervertebral disk degeneration
1) Confidence 0.39 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875625 Disease Relevance 0.17 Pain Relevance 0

General Comments

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