INT311950

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.15
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (FBN1, PGF) cell differentiation (PGF) signal transduction (PGF)
extracellular space (FBN1) proteinaceous extracellular matrix (FBN1) cell-cell signaling (PGF)
Anatomy Link Frequency
joint 1
capsule 1
FBN1 (Homo sapiens)
PGF (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 26 100.00 Very High Very High Very High
diclofenac 17 90.08 High High
cytokine 21 53.32 Quite High
Infliximab 20 51.04 Quite High
Inflammation 5 50.00 Quite Low
metalloproteinase 2 40.40 Quite Low
Osteoarthritis 2 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
carpal tunnel syndrome 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cirrhosis 5 78.48 Quite High
INFLAMMATION 5 50.00 Quite Low
Necrosis 4 50.00 Quite Low
Cancer 4 50.00 Quite Low
Wound Healing 3 40.48 Quite Low
Contracture 10 5.00 Very Low Very Low Very Low
Injury 8 5.00 Very Low Very Low Very Low
Fibrosis 3 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Osteoarthritis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we could clearly show that human joint capsule MFs express COX2 under in vitro conditions (Figure 7a, b) and significantly upregulate synthesis of PGE2 (Figure 7c), but not PGF1A and PGF2A, upon TNF-?
MFs Positive_regulation (upregulate) of in capsule Gene_expression (synthesis) of PGF2A in joint associated with cox2
1) Confidence 0.00 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875629 Disease Relevance 0.15 Pain Relevance 0.26

General Comments

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