INT311985

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Context Info
Confidence 0.45
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.64
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cd40) extracellular region (Cd40) plasma membrane (Cd40)
enzyme binding (Cd40)
Cd40 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 33 95.72 Very High Very High Very High
cytokine 10 83.32 Quite High
tolerance 8 50.00 Quite Low
rheumatoid arthritis 13 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
abatacept 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Infliximab 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Experimental Arthritis 20 95.72 Very High Very High Very High
Arthritis 14 94.56 High High
Immunization 11 77.20 Quite High
Disease 19 62.64 Quite High
Erythema 6 52.64 Quite High
Pressure And Volume Under Development 9 51.60 Quite High
Rheumatoid Arthritis 13 5.00 Very Low Very Low Very Low
Autoimmune Disease 7 5.00 Very Low Very Low Very Low
Cv General 3 Under Development 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In previous studies we demonstrated that chemical manipulation in DCs through inhibition of IKK, which is responsible for CD40 upregulation in DC, can result in generation of antigen-specific immune regulation and suppression of pathology in the CIA model [15].
Regulation (responsible) of Positive_regulation (upregulation) of CD40 associated with arthritis
1) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.64 Pain Relevance 0.24

General Comments

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