INT312058

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Context Info
Confidence 0.54
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.29
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NAPA)
NAPA (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 12 79.08 Quite High
Inflammation 20 78.24 Quite High
Osteoarthritis 68 12.08 Low Low
cINOD 16 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Analgesic 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 24 78.24 Quite High
Chondrosarcoma 12 76.76 Quite High
Cancer 16 72.32 Quite High
Stress 4 60.72 Quite High
Osteoarthritis 68 12.08 Low Low
Necrosis 12 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Aging 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
protein as substrate both in the absence and in the presence of GlcN and NAPA.
Localization (presence) of NAPA
1) Confidence 0.54 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875647 Disease Relevance 0 Pain Relevance 0
nuclear translocation, GlcN and NAPA should interfere with the NLS presumably by interacting with the lysine residues.
Localization (translocation) of NAPA
2) Confidence 0.54 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875647 Disease Relevance 0 Pain Relevance 0
We tested the ability of GlcN and NAPA to inhibit I?
Localization (ability) of NAPA
3) Confidence 0.47 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875647 Disease Relevance 0.14 Pain Relevance 0.04
NAPA affects not only the nuclear translocation but also the kinase activity of IKK?.
Localization (translocation) of NAPA
4) Confidence 0.47 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875647 Disease Relevance 0.15 Pain Relevance 0.04

General Comments

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