INT312086

Context Info Confidence 0.13 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.64 Pain Relevance 0.39

peptidase activity (ELANE, MMP13) extracellular region (ELANE, MMP13) extracellular space (MMP13) Golgi apparatus (MMP13) proteinaceous extracellular matrix (MMP13) lysosome (MMP13)

Anatomy Link Frequency cleavage 1 ELANE (Homo sapiens) MMP13 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 7 100.00 Osteoarthritis 44 92.64 Inflammatory response 2 87.84 Inflammation 17 57.88 cytokine 3 40.84 cINOD 2 24.04 rheumatoid arthritis 1 20.52 licofelone 3 5.00 COX-2 inhibitor 2 5.00 Arthritis 2 5.00

Disease Link Frequency Relevance Heat Osteoarthritis 48 92.64 INFLAMMATION 22 87.84 Pathologic Processes 1 59.60 Adhesions 1 35.88 Rheumatoid Arthritis 1 20.52 Disease 3 5.00 Arthritis 2 5.00 Pain 1 5.00 Osteophyte 1 5.00 Apoptosis 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

By binding to proteins, HNE activates MMP-13 and increases the susceptibility of type II collagen to proteolytic cleavage by MMP-13 [18].

HNE Positive_regulation (activates) of MMP-13 in cleavage associated with metalloproteinase

1) Confidence 0.13 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.64 Pain Relevance 0.39

General Comments

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