INT312097

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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.75
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (ELANE, ALOX5) nuclear envelope (ALOX5) small molecule metabolic process (ALOX5)
cytosol (ALOX5) peptidase activity (ELANE) extracellular region (ELANE)
Anatomy Link Frequency
chondrocytes 2
ELANE (Homo sapiens)
ALOX5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 220 98.80 Very High Very High Very High
Inflammation 85 97.24 Very High Very High Very High
metalloproteinase 35 89.20 High High
licofelone 15 80.48 Quite High
COX-2 inhibitor 10 55.84 Quite High
cINOD 10 44.20 Quite Low
Pain 5 40.84 Quite Low
Arthritis 10 35.52 Quite Low
Inflammatory mediators 5 32.44 Quite Low
Inflammatory response 10 29.80 Quite Low
Disease Link Frequency Relevance Heat
Osteoarthritis 240 98.80 Very High Very High Very High
Disease 15 97.60 Very High Very High Very High
INFLAMMATION 110 97.24 Very High Very High Very High
Stress 5 70.80 Quite High
Pain 5 40.84 Quite Low
Arthritis 10 35.52 Quite Low
Osteophyte 5 5.00 Very Low Very Low Very Low
Apoptosis 5 5.00 Very Low Very Low Very Low
Necrosis 5 5.00 Very Low Very Low Very Low
Adhesions 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All these data suggest that PGE2 may play a critical role in 5-LOX and FLAP regulation by HNE.
HNE Regulation (regulation) of 5-LOX
1) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.05 Pain Relevance 0.03
These results suggest that 5-LOX and FLAP regulation by HNE is partially mediated via TGF-?
HNE Regulation (regulation) of 5-LOX
2) Confidence 0.07 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.71 Pain Relevance 0.54
HNE-induced changes in the LTB4 level and in 5-LOX and FLAP mRNA expression and were evaluated respectively in picograms per milliliter or as a percentage of control.
HNE-induced Regulation (changes) of 5-LOX
3) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.27 Pain Relevance 0.14
The addition of naproxen to cultured chondrocytes revealed that FLAP and 5-LOX regulation by HNE required PGE2 production.
HNE Regulation (regulation) of 5-LOX in chondrocytes
4) Confidence 0.04 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2875653 Disease Relevance 0.07 Pain Relevance 0.03
In the present study, we investigated the effects of HNE on COX-2/mPGES-1 and 5-LOX pathways regulation in human OA chondrocytes.
HNE Spec (investigated) Regulation (effects) of 5-LOX in chondrocytes associated with osteoarthritis
5) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.64 Pain Relevance 0.32

General Comments

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