INT312101

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Context Info
Confidence 0.21
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.11
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (ALOX5AP) peptidase activity (ELANE) extracellular region (ELANE)
endoplasmic reticulum (ALOX5AP) nucleus (ALOX5AP) enzyme binding (ALOX5AP)
Anatomy Link Frequency
chondrocytes 1
ELANE (Homo sapiens)
ALOX5AP (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 176 93.60 High High
Inflammation 68 86.64 High High
licofelone 12 80.08 Quite High
COX-2 inhibitor 8 55.44 Quite High
cINOD 8 43.80 Quite Low
Pain 4 40.44 Quite Low
Arthritis 8 35.12 Quite Low
Inflammatory mediators 4 32.04 Quite Low
Inflammatory response 8 29.40 Quite Low
metalloproteinase 28 5.12 Low Low
Disease Link Frequency Relevance Heat
Osteoarthritis 192 93.60 High High
INFLAMMATION 88 86.64 High High
Disease 12 73.88 Quite High
Stress 4 70.80 Quite High
Pain 4 40.44 Quite Low
Arthritis 8 35.12 Quite Low
Osteophyte 4 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low
Adhesions 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that 5-LOX and FLAP regulation by HNE is partially mediated via TGF-?
HNE Regulation (regulation) of FLAP
1) Confidence 0.21 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.71 Pain Relevance 0.54
All these data suggest that PGE2 may play a critical role in 5-LOX and FLAP regulation by HNE.
HNE Regulation (regulation) of FLAP
2) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.05 Pain Relevance 0.03
The addition of naproxen to cultured chondrocytes revealed that FLAP and 5-LOX regulation by HNE required PGE2 production.
HNE Regulation (regulation) of FLAP in chondrocytes
3) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2875653 Disease Relevance 0.07 Pain Relevance 0.03
HNE-induced changes in the LTB4 level and in 5-LOX and FLAP mRNA expression and were evaluated respectively in picograms per milliliter or as a percentage of control.
HNE-induced Regulation (changes) of FLAP mRNA
4) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.27 Pain Relevance 0.14

General Comments

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